Abstract

The Library Design and Analysis Core Laboratory (LDA laboratory, Core C) is responsible for assisting with the design of diverse libraries and carrying out the spectroscopic characterization of library members.
The specific aims of the LDA core laboratory are as follows:
Specific Aim 1. The LDA core laboratory will provide the research projects and Synthesis core laboratory with the computational facilities for managing chemical structures and data, for predicting key physicochemical properties of compounds to be synthesized, and for guiding the design of diverse libraries.
Specific Aim 2. The LDA core laboratory will provide automated, high throughput mass spectrometry and NMR analysis to confirm the identity and purity of compounds in libraries.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM069663-03
Application #
7553315
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2005-09-01
Budget End
2006-08-31
Support Year
3
Fiscal Year
2005
Total Cost
$76,422
Indirect Cost

  Institution

Name
University of Kansas Lawrence
Department
Type
DUNS #
076248616
City
Lawrence
State
KS
Country
United States
Zip Code
66045

  Publications

Wang, Xuewei; Jolliffe, Aaron; Carr, Benjamin et al. (2018) Nitric oxide-releasing semi-crystalline thermoplastic polymers: preparation, characterization and application to devise anti-inflammatory and bactericidal implants. Biomater Sci 6:3189-3201
Knewtson, Kelsey E; Rane, Digamber; Peterson, Blake R (2018) Targeting Fluorescent Sensors to Endoplasmic Reticulum Membranes Enables Detection of Peroxynitrite During Cellular Phagocytosis. ACS Chem Biol 13:2595-2602
Ramakumar, Kinthada; Maji, Tapan; Partridge, James J et al. (2017) Synthesis of Spirooxindoles via the tert-Amino Effect. Org Lett 19:4014-4017
Faisal, Saqib; Zang, Qin; Maity, Pradip K et al. (2017) Development and Application of a Recyclable High-Load Magnetic Co/C Hybrid ROMP-Derived Benzenesulfonyl Chloride Reagent and Utility of Corresponding Analogues. Org Lett 19:2274-2277
Koen, Yakov M; Liu, Ke; Shinogle, Heather et al. (2016) Comparative Toxicity and Metabolism of N-Acyl Homologues of Acetaminophen and Its Isomer 3'-Hydroxyacetanilide. Chem Res Toxicol 29:1857-1864
Gold, Ben; Smith, Robert; Nguyen, Quyen et al. (2016) Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis. J Med Chem 59:6027-44
Faisal, Saqib; Maity, Pradip K; Zang, Qin et al. (2016) Application of Silica-Supported Alkylating Reagents in a One-Pot, Sequential Protocol to Diverse Benzoxathiazepine 1,1-Dioxides. ACS Comb Sci 18:387-93
Gowthaman, Ragul; Miller, Sven A; Rogers, Steven et al. (2016) DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites. J Med Chem 59:4152-70
Faisal, Saqib; Maity, Pradip K; Zang, Qin et al. (2016) Synthesis of High-Load, Hybrid Silica-Immobilized Heterocyclic Benzyl Phosphate (Si-OHBP) and Triazolyl Phosphate (Si-OHTP) Alkylating Reagents. ACS Comb Sci 18:394-8
Frankowski, Kevin J; Liu, Ruzhang; Milligan, Gregory L et al. (2015) Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization. Angew Chem Int Ed Engl 54:10555-8

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