Abstract

For the renewal phase of the Broad Institute CMLD, we have proposed a scientific approach partnering innovation and execution. We have defined four interdependent Projects and a highly collaborative Library Synthesis Core, integrated within a single Center with two participating institutions. Meeting our ambitious scientific goals will require tight coordination of our scientific progress with operational excellence and rigorous financial accountability. To this end, we have proposed a plan for administrative management organized around an Administration Core that receives input from all stakeholders (Project/Core leaders, financial administrators of host institutions, external advisors, NIGMS) and provides overall direction to the Broad Institute CMLD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM069721-09
Application #
7932236
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
9
Fiscal Year
2009
Total Cost
$124,282
Indirect Cost

  Institution

Name
Broad Institute, Inc.
Department
Type
DUNS #
623544785
City
Cambridge
State
MA
Country
United States
Zip Code
02142

  Publications

Wawer, Mathias J; Jaramillo, David E; Dan?ík, Vlado et al. (2014) Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles. J Biomol Screen 19:738-48
Gerard, Baudouin; O'Shea, Morgan Welzel; Donckele, Etienne et al. (2014) Correction to Application of a Catalytic Asymmetric Povarov Reaction using Chiral Ureas to the Synthesis of a Tetrahydroquinoline Library. ACS Comb Sci 16:46
Bergonzini, Giulia; Schindler, Corinna S; Wallentin, Carl-Johan et al. (2014) Photoredox Activation and Anion Binding Catalysis in the Dual Catalytic Enantioselective Synthesis of ?-Amino Esters. Chem Sci 5:
Wawer, Mathias J; Li, Kejie; Gustafsdottir, Sigrun M et al. (2014) Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling. Proc Natl Acad Sci U S A 111:10911-6
Over, Björn; McCarren, Patrick; Artursson, Per et al. (2014) Impact of stereospecific intramolecular hydrogen bonding on cell permeability and physicochemical properties. J Med Chem 57:2746-54
Xu, Hao; Zhang, Hu; Jacobsen, Eric N (2014) Chiral sulfinamidourea and strong Brønsted acid-cocatalyzed enantioselective Povarov reaction to access tetrahydroquinolines. Nat Protoc 9:1860-6
Frumm, Stacey M; Fan, Zi Peng; Ross, Kenneth N et al. (2013) Selective HDAC1/HDAC2 inhibitors induce neuroblastoma differentiation. Chem Biol 20:713-25
Rajapaksa, Naomi S; McGowan, Meredeth A; Rienzo, Matthew et al. (2013) Enantioselective total synthesis of (+)-reserpine. Org Lett 15:706-9
Wang, Yikai; Jimenez, Miguel; Sheehan, Patrick et al. (2013) Selective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes. Org Lett 15:1218-21
Lalonde, Mathieu P; McGowan, Meredeth A; Rajapaksa, Naomi S et al. (2013) Enantioselective formal aza-Diels-Alder reactions of enones with cyclic imines catalyzed by primary aminothioureas. J Am Chem Soc 135:1891-4

Showing the most recent 10 out of 71 publications