Animal modeling and the reproducibility of the model are important aspects in obtaining potentially clinicallyas well as biologically relevant information. Thus, the first goal of the Animal Models Core is to provide awell-controlled and consistent source of tissue, blood and plasma samples from animals subjectedto the various models proposed in this grant to the Project leaders. The second goal is to promote theintegration of the results obtained in the various projects with each other as well as to reduce costs and limitthe number of animals required to carry out the proposed studies. By centralizing the expertise andequipment required to carry out the various trauma-hemorrhagic shock (T/HS) and trauma-sham-shock(T/SS) models in one location, the consistency of the results obtained will be increased, while the overallcosts and number of animals used will be significantly reduced. Also by creating an animal registry, theresults observed in specific animal tested in the different projects can be integrated with each other to form amore complete physiologic picture.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
1P50GM069790-01A2
Application #
7074167
Study Section
Special Emphasis Panel (ZGM1-PPBC-5 (TB))
Project Start
2006-07-01
Project End
2011-05-31
Budget Start
2006-07-01
Budget End
2007-05-31
Support Year
1
Fiscal Year
2006
Total Cost
$221,699
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
623946217
City
Newark
State
NJ
Country
United States
Zip Code
07107
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Sheth, Sharvil U; Palange, David; Xu, Da-Zhong et al. (2011) Testosterone depletion or blockade in male rats protects against trauma hemorrhagic shock-induced distant organ injury by limiting gut injury and subsequent production of biologically active mesenteric lymph. J Trauma 71:1652-8
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Qin, Yong; Prescott, Lauriston M; Deitch, Edwin A et al. (2011) Heparin use in a rat hemorrhagic shock model induces biologic activity in mesenteric lymph separate from shock. Shock 35:411-21
Doucet, Danielle; Badami, Chirag; Palange, David et al. (2010) Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats. PLoS One 5:e9421
Doucet, Danielle R; Bonitz, R Paul; Feinman, Rena et al. (2010) Estrogenic hormone modulation abrogates changes in red blood cell deformability and neutrophil activation in trauma hemorrhagic shock. J Trauma 68:35-41
Mohr, Alicia M; Lavery, Robert F; Sifri, Ziad C et al. (2010) Gender differences in glucose variability after severe trauma. Am Surg 76:896-902
Sheth, Sharvil U; Lu, Qi; Twelker, Kate et al. (2010) Intestinal mucus layer preservation in female rats attenuates gut injury after trauma-hemorrhagic shock. J Trauma 68:279-88

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