Animal modeling and the reproducibility of the model are important aspects in obtaining potentially clinicallyas well as biologically relevant information. Thus, the first goal of the Animal Models Core is to provide awell-controlled and consistent source of tissue, blood and plasma samples from animals subjectedto the various models proposed in this grant to the Project leaders. The second goal is to promote theintegration of the results obtained in the various projects with each other as well as to reduce costs and limitthe number of animals required to carry out the proposed studies. By centralizing the expertise andequipment required to carry out the various trauma-hemorrhagic shock (T/HS) and trauma-sham-shock(T/SS) models in one location, the consistency of the results obtained will be increased, while the overallcosts and number of animals used will be significantly reduced. Also by creating an animal registry, theresults observed in specific animal tested in the different projects can be integrated with each other to form amore complete physiologic picture.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
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Special Emphasis Panel (ZGM1-PPBC-5 (TB))
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