PROJECT 3 - HOST-PATHAGEN INTERACTIONS Project Leader: T. Shenk (Molbio) This project is focused on mechanisms intrinsic to the growth and spread of viral, parasitic and bacterial pathogens. Shenk will study mechanisms by which innate immunity limits the replication and spread of human cytomegalovirus, Enquist will explore how pseudorabies virus moves within neurons and spreads between neurons, Llinas will study transcriptional regulation and small molecule metabolism in malaria, Gital/Shaevitz will elucidate the mechanisms by which the peptidoglycan cell wall network of gram-negative bacteria is spatially and temporally organized, and Bassler will study quorum sensing in a variety of bacterial systems.
| Lee, Ha Neul; Mitra, Mithun; Bosompra, Oye et al. (2018) RECK isoforms have opposing effects on cell migration. Mol Biol Cell 29:1825-1838 |
| Garcia, Hernan G; Gregor, Thomas (2018) Live Imaging of mRNA Synthesis in Drosophila. Methods Mol Biol 1649:349-357 |
| Mitra, Mithun; Johnson, Elizabeth L; Swamy, Vinay S et al. (2018) Alternative polyadenylation factors link cell cycle to migration. Genome Biol 19:176 |
| Gibney, Patrick A; Schieler, Ariel; Chen, Jonathan C et al. (2018) Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast. Mol Biol Cell 29:897-910 |
| Mitra, Mithun; Lee, Ha Neul; Coller, Hilary A (2018) Determining Genome-wide Transcript Decay Rates in Proliferating and Quiescent Human Fibroblasts. J Vis Exp : |
| Lee, Andrew H; Dhingra, Satish K; Lewis, Ian A et al. (2018) Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. Sci Rep 8:13578 |
| Bartlett, Thomas M; Bratton, Benjamin P; Duvshani, Amit et al. (2017) A Periplasmic Polymer Curves Vibrio cholerae and Promotes Pathogenesis. Cell 168:172-185.e15 |
| Klibaite, Ugne; Berman, Gordon J; Cande, Jessica et al. (2017) An unsupervised method for quantifying the behavior of paired animals. Phys Biol 14:015006 |
| Sanchez, Monica R; Miller, Aaron W; Liachko, Ivan et al. (2017) Differential paralog divergence modulates genome evolution across yeast species. PLoS Genet 13:e1006585 |
| Matheson, Kinnari; Parsons, Lance; Gammie, Alison (2017) Whole-Genome Sequence and Variant Analysis of W303, a Widely-Used Strain of Saccharomyces cerevisiae. G3 (Bethesda) 7:2219-2226 |
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