Project B: Systems Genetics of Meiotic Recombination;Petko Petkov, Kenneth Paigen (Jackson), Karl Broman (U Wisconsin-Madison) Meiotic recombination is a fundamental biological process required by all sexually reproducing organisms. The placement of recombination events determines inheritance of allelic combinations which is of importance in population genetics and evolution. In our previous work we have identified recombination hotspots whose pattern of activity requires combined action of epistatic regulators. The goal of this project is to identify epistatic genes that interact in networks to control the location and activity of recombination hotspots.
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| Ju, Chelsea J-T; Zhao, Zhuangtian; Wang, Wei (2017) Efficient Approach to Correct Read Alignment for Pseudogene Abundance Estimates. IEEE/ACM Trans Comput Biol Bioinform 14:522-533 |
| Simecek, Petr; Forejt, Jiri; Williams, Robert W et al. (2017) High-Resolution Maps of Mouse Reference Populations. G3 (Bethesda) 7:3427-3434 |
| Tyler, Anna L; Ji, Bo; Gatti, Daniel M et al. (2017) Epistatic Networks Jointly Influence Phenotypes Related to Metabolic Disease and Gene Expression in Diversity Outbred Mice. Genetics 206:621-639 |
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| Parvanov, Emil D; Tian, Hui; Billings, Timothy et al. (2017) PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell 28:488-499 |
| Gu, Tongjun; Gatti, Daniel M; Srivastava, Anuj et al. (2016) Genetic Architectures of Quantitative Variation in RNA Editing Pathways. Genetics 202:787-98 |
| Korstanje, Ron; Deutsch, Konstantin; Bolanos-Palmieri, Patricia et al. (2016) Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria. J Am Soc Nephrol 27:3271-3277 |
| Powers, Natalie R; Parvanov, Emil D; Baker, Christopher L et al. (2016) The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo. PLoS Genet 12:e1006146 |
| Jiang, Zixuan; Harrison, David E; Parsons, Makayla E et al. (2016) Heritability of in vitro phenotypes exhibited by murine adipose-derived stromal cells. Mamm Genome 27:460-8 |
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