Abstract

Mathematics and Computing. The mathematics/computation core consists of computational facilities, teaching facilities, and core faculty available for consultation. Computational facilities include: a 40 node Linux cluster dedicated specifically to mathematical biology (20 Opteron CPU acquired through the support of the P20 planning grant, and 20 Xeon CPU acquired through the HHMI MCSB program), and an additional 48 node mathematics Linux cluster. These are housed and maintained by the staff of the UCI Network and Academic Computing Services department, and are available for use 24/7. Additional computing power is also available though a large cluster provided for bioinformatics by the Institute for Genomics and Bioinformatics (in which many Center members also participate). The budget includes requests for additional computers in the first few years to augment and update the mathematical biology cluster. Dedicated teaching facilities currently include 12 Linux machines in a teaching lab in the department of Mathematics. These machines are connected and can be used as a cluster. Among the faculty available for consultation, five are directly involved in research projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076516-03
Application #
7908919
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
3
Fiscal Year
2009
Total Cost
$468,095
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Yan, Huaming; Konstorum, Anna; Lowengrub, John S (2018) Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth. Bull Math Biol 80:1404-1433
Ranjit, Suman; Malacrida, Leonel; Gratton, Enrico (2018) Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microsc Res Tech 81:980-989
Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883
Staaf, Elina; Hedde, Per Niklas; Bagawath Singh, Sunitha et al. (2018) Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A. Sci Signal 11:
Santos, Rommel A; Fuertes, Ariel J C; Short, Ginger et al. (2018) DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring. Neural Dev 13:22
Koay, Eugene J; Lee, Yeonju; Cristini, Vittorio et al. (2018) A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 24:5883-5894
MacLean, Adam L; Hong, Tian; Nie, Qing (2018) Exploring intermediate cell states through the lens of single cells. Curr Opin Syst Biol 9:32-41
Mäntylä, Elina; Chacko, Jenu V; Aho, Vesa et al. (2018) Viral highway to nucleus exposed by image correlation analyses. Sci Rep 8:1152
Yan, Huaming; Romero-López, Mónica; Benitez, Lesly I et al. (2018) Multiscale modeling of glioblastoma. Transl Cancer Res 7:S96-S98
Lei, Jinzhi; Nie, Qing; Chen, Dong-Bao (2018) A single-cell epigenetic model for paternal psychological stress-induced transgenerational reprogramming in offspring. Biol Reprod 98:846-855

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