Optical Biology. The optical biology core of the Center has a presence in four locations. Each already serves as a resource for optical biology at UCI, but Center funding will allow the purchase of additional equipment related to the aims of the Center (see budget and justification), and will provide for greater coordination of use, sharing of information, and impact on the wider research community. The four locations are 1) the Laboratory for Fluorescence Dynamics (LFD), directed by Enrico Gratton;2) The Beckman Laser Institute (BLI), directed by Bruce Tromberg;3) The Optical Biology Center (OBC) of the Developmental Biology Center, directed by Larry Marsh;and 4) The Laboratory for the Biophysics of Motor-Driven Transport (MDT), directed by Steven Gross. Each facility provides unique equipment and expertise for the optical detection, measurement, and manipulation of spatially-dynamic processes. As previously mentioned in the section on outreach, the LFD and BLI are P41-funded centers actively engaged in the development and dissemination of new technologies. The LFD focuses on advances in correlation spectroscopy and particle tracking. The BLI focuses on novel optical methods for probing tissue-scale properties of biological matter. In addition, the MDT integrates optical tweezers, force measurements, particle tracking and image analysis. The OBC is not directly charged with developing new technology, but rather with providing access and training in a wide variety of biological applications of confocal fluorescence microscopy and (e.g. involving photoconvertible probes, FCS, FRET, etc.). The OBC also distributes a quarterly newsletter to keep investigators informed of the latest developments in fluorescence microscopy. Each of these facilities possesses unique hardware and software available for use by the Center's members and its visitors. This core also plays an important role in education and training, as discussed in the next section.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076516-04
Application #
8119571
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2010-08-01
Budget End
2011-07-31
Support Year
4
Fiscal Year
2010
Total Cost
$330,138
Indirect Cost
Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Hedde, Per Niklas; Gratton, Enrico (2018) Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens. Microsc Res Tech 81:924-928
Kobylkevich, Brian M; Sarkar, Anyesha; Carlberg, Brady R et al. (2018) Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity. Phys Biol 15:036005
Sameni, Sara; Malacrida, Leonel; Tan, Zhiqun et al. (2018) Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Sci Rep 8:734
Konstorum, Anna; Lowengrub, John S (2018) Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model. J Theor Biol 439:86-99
Yan, Huaming; Konstorum, Anna; Lowengrub, John S (2018) Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth. Bull Math Biol 80:1404-1433
Ranjit, Suman; Malacrida, Leonel; Gratton, Enrico (2018) Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microsc Res Tech 81:980-989
Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883
Staaf, Elina; Hedde, Per Niklas; Bagawath Singh, Sunitha et al. (2018) Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A. Sci Signal 11:
Santos, Rommel A; Fuertes, Ariel J C; Short, Ginger et al. (2018) DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring. Neural Dev 13:22
Koay, Eugene J; Lee, Yeonju; Cristini, Vittorio et al. (2018) A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 24:5883-5894

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