Systems Biology seeks to explain the complexity of life by revealing the basic strategies used by organisms to carry out diverse, demanding tasks in an uncertain world. Many Systems Biological approaches focus on the dynamic nature of living systems, but cells, tissues, and organisms don't just vary in time, they vary in space. Patterns must be specified, shapes and sizes must be controlled, and transport of signals and cargoes from one location to another must be regulated. For the last 4-1/2 years, the Center for Complex Biological Systems at the University of California, Irvine has operated as a National Center for Systems Biology, with a focus on Spatial Dynamics, the study of spatial phenomena and spatial design principles in biology. Taking advantage of collective strength in modeling, imaging and experimental methods, teams of molecular and cellular biologists, mathematicians, computer scientists, physicists and engineers have worked together to tackle a variety of spatial problems, from the subcellular to the organ level. During the next five years, the center proposes to extend this work with new research in five theme areas: pattern formation;tissue growth control;spatial control of intracellular signaling;development of mathematical and computational tools;and developmental of optical tools for spatial dynamics and nano-imaging. In addition, the center will maintain and expand upon an array of educational and outreach activities developed during the current funding period, including graduate, undergraduate and high school training activities;a short course for professionals in Systems Biology;faculty recruiting;symposia, workshops, regional meetings, retreats, and activities aimed at promoting workforce diversity.
Spatially dynamic processes are crucial to development, regeneration, wound healing, and gene expression. Understanding such processes will provide deep insights into diverse pathological processes ranging from birth defects, to cancer, to aging. Training and outreach in Systems Biology will help prepare the scientific workforce to tackle the complex, multi-disciplinary challenges of investigating biological spatial dynamics.
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|Rackauckas, Christopher; Schilling, Thomas; Nie, Qing (2018) Mean-Independent Noise Control of Cell Fates via Intermediate States. iScience 3:11-20|
|Malacrida, Leonel; Gratton, Enrico (2018) LAURDAN fluorescence and phasor plots reveal the effects of a H2O2 bolus in NIH-3T3 fibroblast membranes dynamics and hydration. Free Radic Biol Med 128:144-156|
|Malacrida, Leonel; Rao, Estella; Gratton, Enrico (2018) Comparison between iMSD and 2D-pCF analysis for molecular motion studies on in vivo cells: The case of the epidermal growth factor receptor. Methods 140-141:74-84|
|Hedde, Per Niklas; Gratton, Enrico (2018) Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens. Microsc Res Tech 81:924-928|
|Kobylkevich, Brian M; Sarkar, Anyesha; Carlberg, Brady R et al. (2018) Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity. Phys Biol 15:036005|
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|Konstorum, Anna; Lowengrub, John S (2018) Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model. J Theor Biol 439:86-99|
|Yan, Huaming; Konstorum, Anna; Lowengrub, John S (2018) Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth. Bull Math Biol 80:1404-1433|
|Ranjit, Suman; Malacrida, Leonel; Gratton, Enrico (2018) Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microsc Res Tech 81:980-989|
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