THEME A - CONTROL OF PATTERN (Arthur Lander, Theme Leader) I Understanding pattern - the regular arrangement of cells and cellular behaviors in space - is one of the oldest problems in biology. Over the past half-century, two views of pattern formation have flourished [63,64], both appealing to the actions of molecules, termed morphogens, that spread within tissues. In """"""""boundary-organized' patterning, long-range morphogen gradients provide positional Information, giving cells their coordinates with respect to a frame of reference. In """"""""self-organizing"""""""" patterning, morphogens act over shorter range to induce or repress expression of themselves or other morphogens, which in turn influences their own activity. Such feedback creates instabilities that lead to spontaneous division of cell groups into repeating units.
Aim A l , below, explores changing concepts in how long-range morphogens control pattern.
Aim A2 pursues the idea that patterning is often neither boundary- nor self-organized, but a combination of both.
A third aim explores how pattern control and growth control are coordinated (it is designated Aim ABS, to reflect the fact that it will be a joint effort between Theme A [pattern] and Theme B [growth control]).
|Hedde, Per Niklas; Gratton, Enrico (2018) Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens. Microsc Res Tech 81:924-928|
|Kobylkevich, Brian M; Sarkar, Anyesha; Carlberg, Brady R et al. (2018) Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity. Phys Biol 15:036005|
|Sameni, Sara; Malacrida, Leonel; Tan, Zhiqun et al. (2018) Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Sci Rep 8:734|
|Konstorum, Anna; Lowengrub, John S (2018) Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model. J Theor Biol 439:86-99|
|Yan, Huaming; Konstorum, Anna; Lowengrub, John S (2018) Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth. Bull Math Biol 80:1404-1433|
|Ranjit, Suman; Malacrida, Leonel; Gratton, Enrico (2018) Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microsc Res Tech 81:980-989|
|Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883|
|Staaf, Elina; Hedde, Per Niklas; Bagawath Singh, Sunitha et al. (2018) Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A. Sci Signal 11:|
|Santos, Rommel A; Fuertes, Ariel J C; Short, Ginger et al. (2018) DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring. Neural Dev 13:22|
|Koay, Eugene J; Lee, Yeonju; Cristini, Vittorio et al. (2018) A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 24:5883-5894|
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