Abstract

THEME B: CONTROL OF GROWTH AND MORPHOGENESIS (Anne Calof, Theme Leader) I Epithelia are organized sheets of cells that play a central role in determining the sizes and 3D architectures of our organs. Ducts, lobules, buds, alveoli, even stem cell niches, all take their form through the actions of epithelia during development. During the past grant period, through studies of the mouse olfactory epithelium OE), we made great progress in understanding how negative feedback control of self-renewal is used to achieve robust size homeostasis and rapid regeneration [19-24]. This strategy solves some of the problems that epithelia face, but not others, such as control of planar expansion;creation of morphogenetic units;and protection of cell lineages from accumulated damage. Here we take up these questions, returning to the OE, but also introducing two new systems: the mouse intestinal epithelium (IE) and the C. elegans gonad.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076516-08
Application #
8731906
Study Section
Special Emphasis Panel (ZGM1-CBCB-3)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
8
Fiscal Year
2014
Total Cost
$365,574
Indirect Cost
$125,964

  Institution

Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Hedde, Per Niklas; Gratton, Enrico (2018) Selective plane illumination microscopy with a light sheet of uniform thickness formed by an electrically tunable lens. Microsc Res Tech 81:924-928
Kobylkevich, Brian M; Sarkar, Anyesha; Carlberg, Brady R et al. (2018) Reversing the direction of galvanotaxis with controlled increases in boundary layer viscosity. Phys Biol 15:036005
Sameni, Sara; Malacrida, Leonel; Tan, Zhiqun et al. (2018) Alteration in Fluidity of Cell Plasma Membrane in Huntington Disease Revealed by Spectral Phasor Analysis. Sci Rep 8:734
Konstorum, Anna; Lowengrub, John S (2018) Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model. J Theor Biol 439:86-99
Yan, Huaming; Konstorum, Anna; Lowengrub, John S (2018) Three-Dimensional Spatiotemporal Modeling of Colon Cancer Organoids Reveals that Multimodal Control of Stem Cell Self-Renewal is a Critical Determinant of Size and Shape in Early Stages of Tumor Growth. Bull Math Biol 80:1404-1433
Ranjit, Suman; Malacrida, Leonel; Gratton, Enrico (2018) Differences between FLIM phasor analyses for data collected with the Becker and Hickl SPC830 card and with the FLIMbox card. Microsc Res Tech 81:980-989
Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883
Staaf, Elina; Hedde, Per Niklas; Bagawath Singh, Sunitha et al. (2018) Educated natural killer cells show dynamic movement of the activating receptor NKp46 and confinement of the inhibitory receptor Ly49A. Sci Signal 11:
Santos, Rommel A; Fuertes, Ariel J C; Short, Ginger et al. (2018) DSCAM differentially modulates pre- and postsynaptic structural and functional central connectivity during visual system wiring. Neural Dev 13:22
Koay, Eugene J; Lee, Yeonju; Cristini, Vittorio et al. (2018) A Visually Apparent and Quantifiable CT Imaging Feature Identifies Biophysical Subtypes of Pancreatic Ductal Adenocarcinoma. Clin Cancer Res 24:5883-5894

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