Abstract

The primary objectives of this subproject are to test the hypotheses: 1): Protocolized resuscitation reduces expression of circulating markers of: i.) inflammation, ii.) cellular hypoxia, iii.) oxidative stress, and iv.) coagulation/thrombosis. 2): The clinical efficacy of protocolized resuscitation is associated with reduced expression of circulating markers of: i.) inflammation, ii.) cellular hypoxia, iii.) oxidative stress, and iv.) coagulation/thrombosis.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076659-04
Application #
7939877
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
4
Fiscal Year
2009
Total Cost
$341,282
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Higgins, Sarah J; De Ceunynck, Karen; Kellum, John A et al. (2018) Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest 128:1471-1484
Massey, Michael J; Hou, Peter C; Filbin, Michael et al. (2018) Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial. Crit Care 22:308
Fabian-Jessing, Bjorn K; Massey, Michael J; Filbin, Michael R et al. (2018) In vivo quantification of rolling and adhered leukocytes in human sepsis. Crit Care 22:240
PRISM Investigators; Rowan, Kathryn M; Angus, Derek C et al. (2017) Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. N Engl J Med 376:2223-2234
Kellum, John A; Pike, Francis; Yealy, Donald M et al. (2017) Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study. Crit Care Med 45:438-445
Hou, Peter C; Filbin, Michael R; Wang, Henry et al. (2017) Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial. Chest 152:22-31
Kellum, John A; Chawla, Lakhmir S; Keener, Christopher et al. (2016) The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock. Am J Respir Crit Care Med 193:281-7
Angus, Derek C; Seymour, Christopher W; Coopersmith, Craig M et al. (2016) A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria. Crit Care Med 44:e113-21
Puskarich, Michael A; Shapiro, Nathan I; Massey, Michael J et al. (2016) Lactate Clearance in Septic Shock Is Not a Surrogate for Improved Microcirculatory Flow. Acad Emerg Med 23:690-3
Armen, Scott B; Freer, Carol V; Showalter, John W et al. (2016) Improving Outcomes in Patients With Sepsis. Am J Med Qual 31:56-63

Showing the most recent 10 out of 58 publications