Abstract

The mandate of the Data Management and Analysis Core (DMAC) is to direct the planning, design, implementation and testing of the data management system and ensure that all analyses are of high quality and yield statistically valid results. The DMAC will coordinate and integrate efficient and consistent utilization of data and statistical resources across the subprojects by providing standard methodology and staff support that are readily accessible to investigators. DMAC will support each subproject is as follows: Subproject 1 (Clinical efficacy). Data acquisition;Monitoring of data quality and integrity;Auditing of clinical protocols;Enrolment tracking and reporting. Subproject 2 (Mechanisms of action). Real-time sample tracking;recording and security of linkage codes for samples to clinical data. Subproject 3 (Costs and cost-effectiveness). Cost data acquisition;Monitoring of data quality and integrity. All subprojects. Database development;Data entry and analysis;Data confidentiality.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
5P50GM076659-05
Application #
8146193
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
2013-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$210,863
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Higgins, Sarah J; De Ceunynck, Karen; Kellum, John A et al. (2018) Tie2 protects the vasculature against thrombus formation in systemic inflammation. J Clin Invest 128:1471-1484
Massey, Michael J; Hou, Peter C; Filbin, Michael et al. (2018) Microcirculatory perfusion disturbances in septic shock: results from the ProCESS trial. Crit Care 22:308
Fabian-Jessing, Bjorn K; Massey, Michael J; Filbin, Michael R et al. (2018) In vivo quantification of rolling and adhered leukocytes in human sepsis. Crit Care 22:240
PRISM Investigators; Rowan, Kathryn M; Angus, Derek C et al. (2017) Early, Goal-Directed Therapy for Septic Shock - A Patient-Level Meta-Analysis. N Engl J Med 376:2223-2234
Kellum, John A; Pike, Francis; Yealy, Donald M et al. (2017) Relationship Between Alternative Resuscitation Strategies, Host Response and Injury Biomarkers, and Outcome in Septic Shock: Analysis of the Protocol-Based Care for Early Septic Shock Study. Crit Care Med 45:438-445
Hou, Peter C; Filbin, Michael R; Wang, Henry et al. (2017) Endothelial Permeability and Hemostasis in Septic Shock: Results From the ProCESS Trial. Chest 152:22-31
Kellum, John A; Chawla, Lakhmir S; Keener, Christopher et al. (2016) The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock. Am J Respir Crit Care Med 193:281-7
Angus, Derek C; Seymour, Christopher W; Coopersmith, Craig M et al. (2016) A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria. Crit Care Med 44:e113-21
Puskarich, Michael A; Shapiro, Nathan I; Massey, Michael J et al. (2016) Lactate Clearance in Septic Shock Is Not a Surrogate for Improved Microcirculatory Flow. Acad Emerg Med 23:690-3
Armen, Scott B; Freer, Carol V; Showalter, John W et al. (2016) Improving Outcomes in Patients With Sepsis. Am J Med Qual 31:56-63

Showing the most recent 10 out of 58 publications