The UCSF Center for Systems and Synthetic Biology is focused on understanding how cells make decisions using genetically encoded molecular networks. To achieve this goal, we have assembled a diverse group of scientists from different fields who bring different perspectives.
The aims of the Administrative Core are to provide an organizational structure that facilitates our research goals by breaking down barriers between our investigators, creating a strong and interactive community, and recruiting talented young Fellows to our Center. We also aim to disseminate our tools and research to the broader UCSF community, through the organization of local meetings, symposia, and workshops. Finally, we also aim to disseminate the ideas that emerge from our Center through extensive educational outreach and materials ranging from K-12 to graduate education. The administrative core plays an essential role in allowing us to most effectively achieve our goals and disseminate our ideas and findings. LEAD PI: LIM PI's: LIM, EL-SAMAD

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Specialized Center (P50)
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Special Emphasis Panel (ZGM1)
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University of California San Francisco
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Bugaj, L J; Sabnis, A J; Mitchell, A et al. (2018) Cancer mutations and targeted drugs can disrupt dynamic signal encoding by the Ras-Erk pathway. Science 361:
Obernier, Kirsten; Cebrian-Silla, Arantxa; Thomson, Matthew et al. (2018) Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation. Cell Stem Cell 22:221-234.e8
Toda, Satoshi; Blauch, Lucas R; Tang, Sindy K Y et al. (2018) Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science 361:156-162
Tsvetanova, Nikoleta G; Trester-Zedlitz, Michelle; Newton, Billy W et al. (2017) G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands. Mol Pharmacol 91:145-156
Srinivas, Niranjan; Parkin, James; Seelig, Georg et al. (2017) Enzyme-free nucleic acid dynamical systems. Science 358:
Stewart-Ornstein, Jacob; Chen, Susan; Bhatnagar, Rajat et al. (2017) Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell 28:221-227
Tsai, Yu-Hwai; Nattiv, Roy; Dedhia, Priya H et al. (2017) In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development 144:1045-1055
Aranda-Díaz, Andrés; Mace, Kieran; Zuleta, Ignacio et al. (2017) Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast. ACS Synth Biol 6:545-554
Lim, Wendell A; June, Carl H (2017) The Principles of Engineering Immune Cells to Treat Cancer. Cell 168:724-740
Nissen, Kelly E; Homer, Christina M; Ryan, Colm J et al. (2017) The histone variant H2A.Z promotes splicing of weak introns. Genes Dev 31:688-701

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