COLLABORATIONS AND DEVELOPMENT FUNDAn essential part of the HARC Center will be to enlist a wide range of collaborators to help furtheridentify and validate HIV-host protein complexes, facilitate structure determination of the complexes, utilizestructural information to more deeply probe the biological functions of the HIV regulatory and accessoryproteins, and extend technological developments in high-throughput expression, structure determination, MSmethods, cryo-EM, and tomography. We will facilitate these essential collaborations by: actively reaching outto relevant researchers through direct contacts; organizing visits of collaborators and possible collaboratorsto the HARC Center to plan future research directions; providing seed funding for promising collaborations;facilitating funding opportunities for collaborators, including the related R21/R33 mechanism announced byNIAID; widely disseminating the goals, results, and available resources of the HARC Center to encouragefurther outside participation; and actively participating in national and international meetings. We haverequested 5% of the direct cost budget for a Collaboration Development Fund to support these activities.Given the breadth of projects encompassed in the initial establishment of the HARC Center, we havesolicited letters from potential collaborators working directly on the accessory and regulatory proteins andtechnologies that comprise the focus of this project. As the HARC Center becomes more established, newresearch directions will be evaluated thoroughly by the HARC Center Executive Council and internal andexternal advisory committees, and directions altered and funds allocated as appropriate. Our initialcollaborative efforts are described in more detail in Section IV.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Specialized Center (P50)
Project #
1P50GM082250-01
Application #
7480074
Study Section
Special Emphasis Panel (ZRG1-AARR-A (40))
Project Start
2007-09-01
Project End
2012-07-31
Budget Start
2007-09-01
Budget End
2008-07-31
Support Year
1
Fiscal Year
2007
Total Cost
$191,127
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Ivry, Sam L; Meyer, Nicole O; Winter, Michael B et al. (2018) Global substrate specificity profiling of post-translational modifying enzymes. Protein Sci 27:584-594
Cary, Daniele C; Peterlin, B Matija (2018) Procyanidin trimer C1 reactivates latent HIV as a triple combination therapy with kansui and JQ1. PLoS One 13:e0208055
Palovcak, Eugene; Wang, Feng; Zheng, Shawn Q et al. (2018) A simple and robust procedure for preparing graphene-oxide cryo-EM grids. J Struct Biol 204:80-84
Tambe, Akshay; East-Seletsky, Alexandra; Knott, Gavin J et al. (2018) RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a. Cell Rep 24:1025-1036
Paulo, Esther; Wu, Dongmei; Wang, Yangmeng et al. (2018) Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis. Sci Rep 8:11001
Faust, Tyler B; Li, Yang; Bacon, Curtis W et al. (2018) The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife 7:
Eckhardt, Manon; Zhang, Wei; Gross, Andrew M et al. (2018) Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network. Cancer Discov 8:1474-1489
Masand, Ruchi; Paulo, Esther; Wu, Dongmei et al. (2018) Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits. Cell Metab 27:616-629.e4
Binning, Jennifer M; Smith, Amber M; Hultquist, Judd F et al. (2018) Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors. PLoS Pathog 14:e1006830
Morris, Kyle L; Buffalo, Cosmo Z; St├╝rzel, Christina M et al. (2018) HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation. Cell 174:659-671.e14

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