COLLABORATIONS AND DEVELOPMENT FUNDAn essential part of the HARC Center will be to enlist a wide range of collaborators to help furtheridentify and validate HIV-host protein complexes, facilitate structure determination of the complexes, utilizestructural information to more deeply probe the biological functions of the HIV regulatory and accessoryproteins, and extend technological developments in high-throughput expression, structure determination, MSmethods, cryo-EM, and tomography. We will facilitate these essential collaborations by: actively reaching outto relevant researchers through direct contacts; organizing visits of collaborators and possible collaboratorsto the HARC Center to plan future research directions; providing seed funding for promising collaborations;facilitating funding opportunities for collaborators, including the related R21/R33 mechanism announced byNIAID; widely disseminating the goals, results, and available resources of the HARC Center to encouragefurther outside participation; and actively participating in national and international meetings. We haverequested 5% of the direct cost budget for a Collaboration Development Fund to support these activities.Given the breadth of projects encompassed in the initial establishment of the HARC Center, we havesolicited letters from potential collaborators working directly on the accessory and regulatory proteins andtechnologies that comprise the focus of this project. As the HARC Center becomes more established, newresearch directions will be evaluated thoroughly by the HARC Center Executive Council and internal andexternal advisory committees, and directions altered and funds allocated as appropriate. Our initialcollaborative efforts are described in more detail in Section IV.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1-AARR-A (40))
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University of California San Francisco
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