The kidney plays a primary role in the long term control of arterial pressure [159-161]. Thus any attempt at modeling the causes and effects of hypertension on cardiovascular system will require accounting for renal function. This project will develop two connected models (Figure 2.11) of renal function. A physiological model will simulate blood flow, transport, and epithelial cell metabolism;a gene-level, molecular model will simulate transcriptional, signaling, and biochemical mechanisms related specifically to superoxide in a single nephron segment, the medullary thick ascending limb (mTAL). The two models will be integrated through the regulation of medullary blood flow. The innovative approach of integrating physiological modeling with pathway-specific molecular modeling is expected to generate novel hypotheses regarding gene-disease relationships in several rat models.
| Williams, Nakeya D; Mehlsen, Jesper; Tran, Hien T et al. (2018) An optimal control approach for blood pressure regulation during head-up tilt. Biol Cybern : |
| Olsen, Christian Haargaard; Ottesen, Johnny T; Smith, Ralph C et al. (2018) Parameter subset selection techniques for problems in mathematical biology. Biol Cybern : |
| Wright, Peter T; Bhogal, Navneet K; Diakonov, Ivan et al. (2018) Cardiomyocyte Membrane Structure and cAMP Compartmentation Produce Anatomical Variation in ?2AR-cAMP Responsiveness in Murine Hearts. Cell Rep 23:459-469 |
| Ciocanel, Maria-Veronica; Docken, Steffen S; Gasper, Rebecca E et al. (2018) Cardiovascular regulation in response to multiple hemorrhages: analysis and parameter estimation. Biol Cybern : |
| Qureshi, M Umar; Colebank, Mitchel J; Schreier, David A et al. (2018) Characteristic impedance: frequency or time domain approach? Physiol Meas 39:014004 |
| Herum, Kate M; Choppe, Jonas; Kumar, Aditya et al. (2017) Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell 28:1871-1882 |
| McClymont, Darryl; Teh, Irvin; Carruth, Eric et al. (2017) Evaluation of non-Gaussian diffusion in cardiac MRI. Magn Reson Med 78:1174-1186 |
| Sturdy, Jacob; Ottesen, Johnny T; Olufsen, Mette S (2017) Modeling the differentiation of A- and C-type baroreceptor firing patterns. J Comput Neurosci 42:11-30 |
| Dewan, Sukriti; McCabe, Kimberly J; Regnier, Michael et al. (2016) Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation-An Integrated Multiscale Modeling Study. J Phys Chem B 120:8264-75 |
| Lee, Pilhwa; Carlson, Brian E; Chesler, Naomi et al. (2016) Heterogeneous mechanics of the mouse pulmonary arterial network. Biomech Model Mechanobiol 15:1245-61 |
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