Abstract

At this writing, the Cleveland Major Research Project is in the fourth year of operation. Our goals are unchanged. Significant maturation has occurred in the research protocols. We continue to study aberrant maternal and fetal metabolic systems with emphasis on the diabetic mother, fetus, and neonate; the intrauterine growth retarded fetus and neonate; and the prematurely born infant. In this research application metabolic abnormalities are now more closely linked with key fetal systems such as the fetal brain, fetal heart, snd with neonatal neurologic development in order to determine whether demonstrated disordered metabolic systems correlate with disordered organ growth and function. As treatment is applied, most specifically in diabetic patient care, but also in the growth retarded fetus, the effects of the interventions will be related not only to neonatal outcome but to the described study systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD011089-10
Application #
3106142
Study Section
Maternal and Child Health Research Committee (HDMC)
Project Start
1977-07-01
Project End
1987-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
10
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Koontz, M B; Gunzler, D D; Presley, L et al. (2014) Longitudinal changes in infant body composition: association with childhood obesity. Pediatr Obes 9:e141-4
Kalhan, Satish C; Marczewski, Susan E (2012) Methionine, homocysteine, one carbon metabolism and fetal growth. Rev Endocr Metab Disord 13:109-19
Kim, Jaeyeon; Saidel, Gerald M; Kalhan, Satish C (2008) A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases. J Theor Biol 251:523-40
Durnwald, Celeste; Huston-Presley, Larraine; Amini, Saied et al. (2004) Evaluation of body composition of large-for-gestational-age infants of women with gestational diabetes mellitus compared with women with normal glucose tolerance levels. Am J Obstet Gynecol 191:804-8
Okereke, Ndubueze C; Uvena-Celebrezze, Jennifer; Hutson-Presley, Larraine et al. (2002) The effect of gender and gestational diabetes mellitus on cord leptin concentration. Am J Obstet Gynecol 187:798-803
Catalano, P M; Kirwan, J P (2001) Maternal factors that determine neonatal size and body fat. Curr Diab Rep 1:71-7
Uvena-Celebrezze, J; Catalano, P M (2000) The infant of the woman with gestational diabetes mellitus. Clin Obstet Gynecol 43:127-39
Lewy, V D; Danadian, K; Arslanian, S (1999) Determination of body composition in African-American children: validation of bioelectrical impedence with dual energy X-ray absorptiometry. J Pediatr Endocrinol Metab 12:443-8
Catalano, P M; Huston, L; Amini, S B et al. (1999) Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glucose tolerance and gestational diabetes mellitus. Am J Obstet Gynecol 180:903-16
Kalhan, S C; Rossi, K Q; Gruca, L L et al. (1998) Relation between transamination of branched-chain amino acids and urea synthesis: evidence from human pregnancy. Am J Physiol 275:E423-31

Showing the most recent 10 out of 31 publications