Abstract

This study is designed to test both short and long term effects of behavioral intervention on the growth and development of infants with Intrauterine Growth Retardation. The effects of the intervention will be assessed on a group of 150 preterm infants (GA <37 weeks) up to 18 months of age and a second cohort of 105 full-term infants at 3 and 4 years of age. The effects of the intervention will be assessed on mother-infant interaction, caloric intake, growth velocities of weight, length, head circumference, ponderal Index, and skinfold thickness, and developmental outcome (cognitive, linguistic and behavioral status). It is expected that symmetric IUGR preterm infants without intervention will have the lowest feeding interaction scores, the slowest physical growth and poorer developmental outcome. Full-term IUGR infants, without intervention, will have the slowest physical growth and those coming from low SES families, the poorest developmental outcome.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD011343-17
Application #
3756960
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905

  Publications

Stonestreet, Barbara S; Sadowska, Grazyna B; Hanumara, R Choudary et al. (2012) Comparative effects of glucose- and mannitol-induced osmolar stress on blood-brain barrier function in ovine fetuses and lambs. J Cereb Blood Flow Metab 32:115-26
Stonestreet, Barbara S; Sadowska, Grazyna B; Leeman, Joanne et al. (2006) Effects of acute hyperosmolality on blood-brain barrier function in ovine fetuses and lambs. Am J Physiol Regul Integr Comp Physiol 291:R1031-9
Boney, Charlotte M; Verma, Anila; Tucker, Richard et al. (2005) Metabolic syndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 115:e290-6
Petersson, Katherine H; Pinar, Halit; Stopa, Edward G et al. (2004) Effects of exogenous glucose on brain ischemia in ovine fetuses. Pediatr Res 56:621-9
Stonestreet, Barbara S; Petersson, Katherine H; Sadowska, Grazyna B et al. (2004) Regulation of brain water during acute glucose-induced hyperosmolality in ovine fetuses, lambs, and adults. J Appl Physiol 96:553-60
Stonestreet, Barbara S; Oen-Hsiao, Joyce M; Petersson, Katherine H et al. (2003) Regulation of brain water during acute hyperosmolality in ovine fetuses, lambs, and adults. J Appl Physiol 94:1491-500
Vohr, B R; McGarvey, S T (1997) Growth patterns of large-for-gestational-age and appropriate-for-gestational-age infants of gestational diabetic mothers and control mothers at age 1 year. Diabetes Care 20:1066-72
Stonestreet, B S; Patlak, C S; Pettigrew, K D et al. (1996) Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults. Am J Physiol 271:R1594-601
Stonestreet, B S; Boyle, L D; Papparella, A et al. (1996) Circulatory and metabolic effects of alpha-adrenergic blockade in the hyperinsulinemic ovine fetus. J Soc Gynecol Investig 3:241-9
Meyers-Seifer, C H; Vohr, B R (1996) Lipid levels in former gestational diabetic mothers. Diabetes Care 19:1351-6

Showing the most recent 10 out of 38 publications