Abstract

The localization of proteins and MRNAS in animal and human cells and tissues are crucial to our understanding the neuroendocrine and metabolic regulation of the menstrual cycle. Five of the six Units in the Center will examine protein and MRNA distributions to answer key questions regarding hormonal expression, regulation, and site of action. Core C, the histology, immunohistochemistry, and in situ hybridization Core, directed by Dr. Roberts, will centralize these functions in a well equipped laboratory run by experienced personnel. This will optimize and standardize the quality of the results, eliminate the development and perfection of these techniques by the individual Units, and greatly cut material and personnel expenses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD012303-19
Application #
6240872
Study Section
Project Start
1997-04-01
Project End
1999-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
19
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Acevedo-Rodriguez, A; Kauffman, A S; Cherrington, B D et al. (2018) Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling. J Neuroendocrinol 30:e12590
Li, Song; Mbong, Ekaette F; John, Denise T et al. (2018) Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes. Endocrinology 159:1074-1087
Pandolfi, Erica C; Hoffmann, Hanne M; Schoeller, Erica L et al. (2018) Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol 55:8709-8727
Stephens, Shannon B Z; Di Giorgio, Noelia P; Liaw, Reanna B et al. (2018) Estradiol-Dependent and -Independent Stimulation of Kiss1 Expression in the Amygdala, BNST, and Lateral Septum of Mice. Endocrinology 159:3389-3402
Ryan, Genevieve E; Malik, Shaddy; Mellon, Pamela L (2018) Antiandrogen Treatment Ameliorates Reproductive and Metabolic Phenotypes in the Letrozole-Induced Mouse Model of PCOS. Endocrinology 159:1734-1747
Torres, Pedro J; Siakowska, Martyna; Banaszewska, Beata et al. (2018) Gut Microbial Diversity in Women With Polycystic Ovary Syndrome Correlates With Hyperandrogenism. J Clin Endocrinol Metab 103:1502-1511
Hoffmann, Hanne M; Gong, Ping; Tamrazian, Anika et al. (2018) Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol 461:143-154
Belli, Martina; Shimasaki, Shunichi (2018) Molecular Aspects and Clinical Relevance of GDF9 and BMP15 in Ovarian Function. Vitam Horm 107:317-348
Yang, Jennifer A; Hughes, Jessica K; Parra, Ruby A et al. (2018) Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice J Endocrinol 239:339-350
Hoffmann, Hanne; Pandolfi, Erica; Larder, Rachel et al. (2018) Haploinsufficiency of Homeodomain Proteins Six3, Vax1, and Otx2, Causes Subfertility in Mice Via Distinct Mechanisms. Neuroendocrinology :

Showing the most recent 10 out of 217 publications