Abstract

Research in reproductive biology of the female has overshadowed that in the male. Application of basic and clinical studies to solving problems in human reproduction has been more frequent and more successful in females than in males. Work to be described in this application is designed to increase our basic and clinical knowledge of male reproduction. The primary goals of this work are the study of infertility and contraception in men and the exploration of the basic biology of the male reproductive system important in solving these clinical problems. The studies included range from the molecular biology and biochemistry of the brain, pituitary and testis through the physiology of the endocrine control mechanisms for testicular function in adults to clinical studies on the effects of varicoceles on fertility. The efforts of investigators with varied backgrounds and capabilities are directed toward solving major problems of male reproductive biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD012629-18
Application #
2392335
Study Section
Special Emphasis Panel (SRC (SR))
Project Start
1996-04-01
Project End
2001-03-31
Budget Start
1997-04-01
Budget End
1998-03-31
Support Year
18
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Chakraborty, Papia; William Buaas, F; Sharma, Manju et al. (2014) Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components. Mol Endocrinol 28:1055-72
Smith, Benjamin E; Braun, Robert E (2012) Germ cell migration across Sertoli cell tight junctions. Science 338:798-802
Meng, Jing; Greenlee, Anne R; Taub, Chloe J et al. (2011) Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice. Biol Reprod 85:254-60
Burnett, Lindsey A; Blais, Edik M; Unadkat, Jashvant D et al. (2010) Testicular expression of Adora3i2 in Adora3 knockout mice reveals a role of mouse A3Ri2 and human A3Ri3 adenosine receptors in sperm. J Biol Chem 285:33662-70
Carlson, Anne E; Burnett, Lindsey A; del Camino, Donato et al. (2009) Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One 4:e6844
Wolden-Hanson, Tami; Marck, Brett T; Matsumoto, Alvin M (2004) Blunted hypothalamic neuropeptide gene expression in response to fasting, but preservation of feeding responses to AgRP in aging male Brown Norway rats. Am J Physiol Regul Integr Comp Physiol 287:R138-46
Sohn, Elliott H; Wolden-Hanson, Tami; Matsumoto, Alvin M (2002) Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript Endocrinology 143:954-63
Wolden-Hanson, Tami; Marck, Brett T; Matsumoto, Alvin M (2002) Troglitazone treatment of aging Brown Norway rats improves food intake and weight gain after fasting without increasing hypothalamic NPY gene expression. Exp Gerontol 37:679-91
Amory, J K; Anawalt, B D; Bremner, W J et al. (2001) Daily testosterone and gonadotropin levels are similar in azoospermic and nonazoospermic normal men administered weekly testosterone: implications for male contraceptive development. J Androl 22:1053-60
Finn, P D; Cunningham, M J; Rickard, D G et al. (2001) Serotonergic neurons are targets for leptin in the monkey. J Clin Endocrinol Metab 86:422-6

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