Project I will examine the neurobiological underpinnings of Attention- Deficit/Hyperactivity Disorder (ADHD), using functional magnetic resonance imaging (fMRI) to study children recruited in the initial Center program. Specifically, children initially assessed at 7.5-13.3 years will be systematically re-evaluated at ages 11-16 years. The sample and the significant progress made by our research group in using fMRI allow us to address four specific aims: 1. To determine the functional organization of the brain (using fMRI) in ADHD and within subgroups of ADHD (ADHD/IT, ADHD/CT), to determine whether particular brain activation patterns provide a """"""""signature"""""""" for specific subgroups identified during the initial project period. 2. To determine the influence of comorbidity with RD on brain activation patterns (comparing ADHD without RD and ADHD with RD). 3. To determine the effects of pharmacotherapy on brain activation patterns: a) within subgroups of ADHD and b) between groups of children comorbid for ADHD and RD, i.e., ADHD without RD and ADHD with RD. 4. To relate brain activation patterns as determined with fMRI to changes in cognitive (particularly attentional and linguistic) processes comparing: a) ADHD with normals; b) within subgroups of ADHD (ADHD Inattentive vs ADHD combined type); c) ADHD with and without RD; d) effects of pharmacotherapy.
| Estrada, Eduardo; Ferrer, Emilio; Shaywitz, Bennett A et al. (2018) Identifying atypical change at the individual level from childhood to adolescence. Dev Psychol 54:2193-2206 |
| Lebel, Catherine; Shaywitz, Bennett; Holahan, John et al. (2013) Diffusion tensor imaging correlates of reading ability in dysfluent and non-impaired readers. Brain Lang 125:215-22 |
| Ferrer, Emilio; Shaywitz, Bennett A; Holahan, John M et al. (2010) Uncoupling of reading and IQ over time: empirical evidence for a definition of dyslexia. Psychol Sci 21:93-101 |
| Shaywitz, Sally E; Shaywitz, Bennett A (2008) Paying attention to reading: the neurobiology of reading and dyslexia. Dev Psychopathol 20:1329-49 |
| Shaywitz, Sally E; Morris, Robin; Shaywitz, Bennett A (2008) The education of dyslexic children from childhood to young adulthood. Annu Rev Psychol 59:451-75 |
| Noble, Kimberly G; McCandliss, Bruce D; Farah, Martha J (2007) Socioeconomic gradients predict individual differences in neurocognitive abilities. Dev Sci 10:464-80 |
| Shaywitz, Sally E; Gruen, Jeffrey R; Shaywitz, Bennett A (2007) Management of dyslexia, its rationale, and underlying neurobiology. Pediatr Clin North Am 54:609-23, viii |
| Shaywitz, Bennett A; Skudlarski, Pawel; Holahan, John M et al. (2007) Age-related changes in reading systems of dyslexic children. Ann Neurol 61:363-70 |
| Burgio-Murphy, Andrea; Klorman, Rafael; Shaywitz, Sally E et al. (2007) Error-related event-related potentials in children with attention-deficit hyperactivity disorder, oppositional defiant disorder, reading disorder, and math disorder. Biol Psychol 75:75-86 |
| Noble, Kimberly G; Wolmetz, Michael E; Ochs, Lisa G et al. (2006) Brain-behavior relationships in reading acquisition are modulated by socioeconomic factors. Dev Sci 9:642-54 |
Showing the most recent 10 out of 50 publications
