Posterior vaginal wall prolapse (PVP), including enterocele and rectocele, is an enigmatic condition whose pathophysiology is poorly understood. ORWH, NICHD and NIDDK have each identified that female pelvic floor disorders such as PVP are in critical need of pathophysiology research. Competing hypotheses have been proposed relating to the causal roles of endopelvic fascia or levator ani muscle failure. However, data to resolve these conflicts are not available and are needed to establish the relative contributions of fascial and muscular abnormalities to PVP. This study will test the mechanistic hypothesis that the occurrence of PVP is not explained by a single mechanism but involves the interaction between fascial and muscle abnormalities. To test these hypotheses, we will recruit 75 cases with PVP and 75 controls of similar age and race.
Aim 1. """"""""Fascia"""""""", we will use mid-sagittal MR images made during maximal Valsalva to document the posterior wall location and morphology in 4 regions influenced by fascial support: 1) location of the posterior vaginal apex, 2) length of the posterior vaginal wall, 3) changes in the inclination of the distal vaginal wall, and 4) location of the perineal body. By comparing measurements between cases and controls, we will determine the contributions of abnormalities in each region to the occurrence and size of PVP.
Aim 2. """"""""Muscle"""""""", we will use multiplanar proton density MR scans to compare 1) presence of visible defects in the levator ani muscles, 2) cross sectional areas of the muscle, as well as measuring and 3) pelvic muscle contraction force during a maximal contraction. Using these data we will determine the contribution of muscular abnormalities. We will then use statistical modeling to determine the relative contributions of fascial versus muscular abnormalities.
Aim 3. """"""""Rectocele vs. Enterocele"""""""", we will test the strength of association between the 4 fascial and 3 muscle abnormalities and the two types of PVP using general linear modeling.
Aim 4, """"""""Biomechanical Modeling"""""""", we will use biomechanical analyses of fascia and muscle interactions in computer-based models to investigate patterns of muscle and connective tissue support site failures that lead to PVP. These insights are needed to advance our understanding of disease mechanisms so that we can reduce the 30% recurrence rate of prolapse after surgery, and develop preventative strategies to reduce the need for surgery in 200,000 women each year.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD044406-09
Application #
8134473
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
9
Fiscal Year
2010
Total Cost
$231,367
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Swenson, Carolyn W; Morgan, Daniel M; George, Jenny et al. (2018) Effect of Cystocele Repair on Cervix Location in Women With Uterus In Situ. Female Pelvic Med Reconstr Surg 24:56-59
Huebner, Markus; DeLancey, John O L; Reisenauer, Christl et al. (2018) Magnetic resonance imaging of vaginal support structure before and after Vecchietti procedure in women with Mayer-Rokitansky-K├╝ster-Hauser syndrome. Acta Obstet Gynecol Scand 97:830-837
Masteling, Mariana; Ashton-Miller, James A; DeLancey, John O L (2018) Technique development and measurement of cross-sectional area of the pubovisceral muscle on MRI scans of living women. Int Urogynecol J :
Tracy, Paige V; Wadhwani, Shreya; Triebwasser, Jourdan et al. (2018) On the variation in maternal birth canal in vivo viscoelastic properties and their effect on the predicted length of active second stage and levator ani tears. J Biomech 74:64-71
Sammarco, Anne G; Swenson, Carolyn W; Kamdar, Neil S et al. (2018) Rate of Pelvic Organ Prolapse Surgery Among Privately Insured Women in the United States, 2010-2013. Obstet Gynecol 131:484-492
Berger, Mitchell B; Kolenic, Giselle E; Fenner, Dee E et al. (2018) Structural, functional, and symptomatic differences between women with rectocele versus cystocele and normal support. Am J Obstet Gynecol 218:510.e1-510.e8
Tracy, Paige V; Wineman, Alan S; Orejuela, Francisco J et al. (2018) A constitutive model description of the in vivo material properties of lower birth canal tissue during the first stage of labor. J Mech Behav Biomed Mater 79:213-218
Sammarco, Anne G; Nandikanti, Lahari; Kobernik, Emily K et al. (2017) Interactions among pelvic organ protrusion, levator ani descent, and hiatal enlargement in women with and without prolapse. Am J Obstet Gynecol 217:614.e1-614.e7
Harris, John A; Sammarco, Anne G; Swenson, Carolyn W et al. (2017) Are perioperative bundles associated with reduced postoperative morbidity in women undergoing benign hysterectomy? Retrospective cohort analysis of 16,286 cases in Michigan. Am J Obstet Gynecol 216:502.e1-502.e11
DeLancey, John O L (2017) ""Mommy, how will the baby get out of your tummy? Will it hurt you?"" Am J Obstet Gynecol 217:110-111

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