Core A: Sex Differences Administrative Support Core will be responsible for the following five services to coordinate the three projects in this SCOR.
Aim 1 : Administration: Core A will provide administrative support to Projects 1,11, and 111 for recruitment. subject scheduling, forms generation, IRB issues, organization, and confidential filing. Centralized support will decrease cost and increase effectiveness.
Aim 2 : Human Subjects: Core A will assure ongoing safety of human subjects through active involvement with our IRB committee. This involvement will assure compliance with institutional and national regulations, track and assess subject safety by monitoring adverse events, and provide information to outside subject safety committee (DSMB) as necessary. This core will prepare regular reports from centralized logs from all Projects concerning adverse events to increase detection of infrequent events that require special attention.
Aim 3 : Fostering Sex and Gender Research: Core A will seek to stimulate further research with the following activities: a) convene an annual SCOR sponsored Pelvic Floor Research Day to foster interdisciplinary discussion across campus along with translational partners and mentees, and b) support, maintain, and expand the SCOR Pelvic Floor Disorders Data Bank of over 1,200 research subjects, totaling over 20,000 images from prior and ongoing projects.
Aim 4 : Budget: Core A will manage the fiscal responsibility of Project I, II, and III along with expenses of Cores A, B, and C. This will include assurance of appropriate distribution of funds to support all three projects throughout the entire length of the funding period.
Aim 5 : Presentation and Manuscript Production: Core A will be responsible for the administrative aspects of the dissemination of data and findings to research and clinical practitioners. Manuscripts and presentations will be submitted and tracked through Core A, allowing immediate translation of important sex-differences research to the community of researchers and physicians who can implement changes and improve prevention and treatment.

Public Health Relevance

The strong central organizing activities of this administrative core will facilitate new discoveries that impact interdisciplinary sex-differences research. By promoting and supporting the broadly interdisciplinary U-M SCOR research team, Core A frees individual investigators from some management effort so they may concentrate on important insights needed to improve prevention and treatment for 3 million women giving birth and 300,000 women suffering from pelvic floor disorders.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
2P50HD044406-11
Application #
8366609
Study Section
Special Emphasis Panel (ZRG1-EMNR-Q (50))
Project Start
Project End
Budget Start
2012-09-22
Budget End
2013-05-31
Support Year
11
Fiscal Year
2012
Total Cost
$255,067
Indirect Cost
$91,037
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Huebner, Markus; DeLancey, John O L; Reisenauer, Christl et al. (2018) Magnetic resonance imaging of vaginal support structure before and after Vecchietti procedure in women with Mayer-Rokitansky-K├╝ster-Hauser syndrome. Acta Obstet Gynecol Scand 97:830-837
Masteling, Mariana; Ashton-Miller, James A; DeLancey, John O L (2018) Technique development and measurement of cross-sectional area of the pubovisceral muscle on MRI scans of living women. Int Urogynecol J :
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Swenson, Carolyn W; Smith, Tovia M; Luo, Jiajia et al. (2017) Intraoperative cervix location and apical support stiffness in women with and without pelvic organ prolapse. Am J Obstet Gynecol 216:155.e1-155.e8
Fairchild, Pamela S; Kamdar, Neil S; Rosen, Emily R et al. (2017) Ligament shortening compared to vaginal colpopexy at the time of hysterectomy for pelvic organ prolapse. Int Urogynecol J 28:899-905

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