Abstract

The overall goal of the Penn Center for the Study of Epigenetics in Reproduction (PennCSER) is to investigate the role of epigenetic gene regulation in reproduction, with a specific emphasis on gametogenesis and early development as they pertain to normal development, implantation and placentation, infertility and Assisted Reproductive Technologies (ART). The Administrative Core will facilitate the successful pursuit of each of the individual projects and enable collaboration among projects. The Core will also organize the solicitation and selection of pilot projects that complement the existing Center program. Finally, the Core will support the Outreach Activities, facilitate training, and assist interactions with the NCTRI network, as well as the internal and external review process.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Specialized Center (P50)
Project #
5P50HD068157-07
Application #
9749188
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
7
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Ghosh, Jayashri; Coutifaris, Christos; Sapienza, Carmen et al. (2017) Global DNA methylation levels are altered by modifiable clinical manipulations in assisted reproductive technologies. Clin Epigenetics 9:14
Vrooman, Lisa A; Bartolomei, Marisa S (2017) Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol 68:72-84
Weinerman, Rachel; Ord, Teri; Bartolomei, Marisa S et al. (2017) The superovulated environment, independent of embryo vitrification, results in low birthweight in a mouse model. Biol Reprod 97:133-142
Vrooman, Lisa A; Xin, Frances; Bartolomei, Marisa S (2016) Morphologic and molecular changes in the placenta: what we can learn from environmental exposures. Fertil Steril 106:930-40
Ghosh, Jayashri; Mainigi, Monica; Coutifaris, Christos et al. (2016) Outlier DNA methylation levels as an indicator of environmental exposure and risk of undesirable birth outcome. Hum Mol Genet 25:123-9
Hur, Stella K; Freschi, Andrea; Ideraabdullah, Folami et al. (2016) Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes. Proc Natl Acad Sci U S A 113:10938-43
Smoak, Evan M; Stein, Paula; Schultz, Richard M et al. (2016) Long-Term Retention of CENP-A Nucleosomes in Mammalian Oocytes Underpins Transgenerational Inheritance of Centromere Identity. Curr Biol 26:1110-6
Weinerman, Rachel; Feng, Rui; Ord, Teri S et al. (2016) Morphokinetic Evaluation of Embryo Development in a Mouse Model: Functional and Molecular Correlates. Biol Reprod 94:84
Castle, Megan; Cleveland, Charlotte; Gordon, Diana et al. (2016) Reproductive Science for High School Students: A Shared Curriculum Model to Enhance Student Success. Biol Reprod 95:28
Luense, Lacey J; Wang, Xiaoshi; Schon, Samantha B et al. (2016) Comprehensive analysis of histone post-translational modifications in mouse and human male germ cells. Epigenetics Chromatin 9:24

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