The Informatics Group will provide computer services, communications, and data security for other Projects in the Center. These services include the rudimentary tasks of supplying computers and operating system software, network operations, system backup and retrieval facilities, and the development intensive tasks of supplying database applications and specialized data analysis applications. With the proposed increaased scope of the Center, the activities of the Informatics group will need to expand accordingly. To provide for the new online data storage requirements of the Center, we will purchase and install hardware to increase our online storage capacity by an order of magnitude, and provide a means of permanent storage for this data. Our heterogeneous client-server database application will be expanded to accommodate the new projects, and allow retrieval of raw data. We will continue to supply customized data analysis and data presentation applications for the specialized needs of the Center, including RH mapping, cosmid contig assembly and human genomic DNA sequencing. Further, to incorporate new capabilities of molecular and genetic analyses across different types of databases, ewe will begin engineering specific enhancements to the Genome Topographer in conjunction with Dr. Tom Marr's group at the Cold Sprint Harbor Laboratory. One of the first new developments will be the development of an automated consistency checking tool, which takes related map elements (genetic, physical, sequence) and automatically checks for consistent order and distance relations. To disseminate the Center's findings, we will further enhance the means of accessing our publicly-available data by including a WorldWideWeb server, and a gopher server.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Specialized Center (P50)
Project #
5P50HG000206-08
Application #
6109087
Study Section
Project Start
1998-07-15
Project End
1999-06-30
Budget Start
Budget End
Support Year
8
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Stewart, E A; McKusick, K B; Aggarwal, A et al. (1997) An STS-based radiation hybrid map of the human genome. Genome Res 7:422-33
Pennacchio, L A; Lehesjoki, A E; Stone, N E et al. (1996) Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1) Science 271:1731-4
Stone, N E; Fan, J B; Willour, V et al. (1996) Construction of a 750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene. Genome Res 6:218-25
Fan, J B; DeYoung, J; Lagace, R et al. (1994) Isolation of yeast artificial chromosome clones from 54 polymorphic loci mapped with high odds on human chromosome 4. Hum Mol Genet 3:243-6
Goold, R D; diSibio, G L; Xu, H et al. (1993) The development of sequence-tagged sites for human chromosome 4. Hum Mol Genet 2:1271-88
Mathews, K D; Mills, K A; Bosch, E P et al. (1992) Linkage localization of facioscapulohumeral muscular dystrophy (FSHD) in 4q35. Am J Hum Genet 51:428-31