Parkland Memorial Hospital provides medical care for a southwestern metroplex area in excess of 2.5 million population. The medical service averages 85 admissions daily. An average of 55 patients are admitted to the cardiology section of the intensive care unit (coronary care unit) per month. The majority of these patients have coronary artery disease. In addition, an average of three new patients with a variety of heart diseases, including angina, are consulted daily by the cardiology service outside of the intensive care unit. A cardiology clinic meets each Friday morning where an average of 80 cardiology patients are seen. The staff will see additional private patients referred to us for evaluation or special diagnostic studies from the community. These patients will be available to enter into this study protocol. The philosophy of carrying out clinical research investigations during the course of a consultation referral has been well accepted by physicians practicing in the Dallas-Fort Worth community reflecting the mutual trust and cooperation that exist between them and the members of the University of Texas Health Science Center at Dallas cardiopulmonary unit. Recognizing these factors, we have every reason to believe that the proposed SCOR program will continue to have wide community-physician acceptance. Based upon past records and the ever-expanding population basis in conjunction with numerous other factors, we feel that the potential for a highly-productive and successful Ischemic SCOR program will continue at the University of Texas Health Science Center at Dallas.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL017669-12
Application #
3106489
Study Section
(SRC)
Project Start
1975-01-01
Project End
1989-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
12
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Wheeler-Clark, E S; Buja, L M (1995) Calcium channel activation mobilizes calcium from a restricted pericellular region surrounding canine coronary artery smooth muscle cells. J Pharmacol Exp Ther 274:1493-506
Muntz, K H; Neyman, S L; Miller, J C (1993) Alterations in alpha 1-adrenergic receptor-mediated phosphatidylinositol turnover in hypoxic cardiac myocytes. J Mol Cell Cardiol 25:1187-202
Butwell, N B; Ramasamy, R; Lazar, I et al. (1993) Effect of lidocaine on contracture, intracellular sodium, and pH in ischemic rat hearts. Am J Physiol 264:H1884-9
Muntz, K H; Sternweis, P C; Gilman, A G et al. (1992) Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes. Mol Biol Cell 3:49-61
Butwell, N B; Ramasamy, R; Sherry, A D et al. (1991) Influence of cardiac pacing on intracellular sodium in the isolated perfused rat heart. Invest Radiol 26:1079-82
Parsons, D; Burton, K P; Hagler, H K et al. (1989) Tension and electrolyte changes with Na+-K+ pump inhibition in rat papillary muscle. Am J Physiol 257:H942-53
Jones, R L; Miller, J C; Hagler, H K et al. (1989) Association between inhibition of arachidonic acid release and prevention of calcium loading during ATP depletion in cultured rat cardiac myocytes. Am J Pathol 135:541-56
Berger, M L; Reynolds, R C; Hagler, H K et al. (1989) Anoxic hepatocyte injury: role of reversible changes in elemental content and distribution. Hepatology 9:219-28
Muntz, K H; Calianos, T A; Buja, L M et al. (1988) Electron microscopic localization of the beta-adrenergic receptor using a ferritin-alprenolol probe. Mol Pharmacol 34:444-51
Wheeler-Clark, E S; Weiss, G B; McGuffee, L J et al. (1986) Cellular redistribution of 45Ca in rabbit renal artery determined by electron microscopic autoradiography: changes in response to K+-induced depolarization and nitrendipine. J Pharmacol Exp Ther 239:286-95

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