Abstract

The Duke University Medical Center Ischemic Heart Disease Specialized Center of Research is a multidisciplinary, interdepartmental, clinical and fundamental research program directed at reduction of death and disability from ischemic heart disease. Specific projects include assessment of the clinical course of patients with angina pectoris and acute myocardial infarction and assessment of the effectiveness of aortocoronary bypass surgery in modifying the outcome. The diagnostic and prognostic significance of exercise induced left ventricular dysfunction as assessed by radionuclide angiocardiography is being evaluated as is the role of echocardiographic techniques in quantitating ventricular wall motion. Other clinical projects are investigating the effects of prolonged exercise training on ventricular function and the use of surgical procedures for the treatment of refractory ventricular arrhythmias. Fundamental research is being carried out on various aspects of myocardial cell metabolism, the effects of ischemia on cellular metabolism and the pharmacokinetics of antiarrhythmic agents in the ischemic myocardium.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL017670-11
Application #
3106496
Study Section
(SRC)
Project Start
1985-01-01
Project End
1989-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Taylor, D A; Silvestry, S C; Bishop, S P et al. (1997) Delivery of primary autologous skeletal myoblasts into rabbit heart by coronary infusion: a potential approach to myocardial repair. Proc Assoc Am Physicians 109:245-53
Silvestry, S C; Taylor, D A; Lilly, R E et al. (1996) The in vivo quantification of myocardial performance in rabbits: a model for evaluation of cardiac gene therapy. J Mol Cell Cardiol 28:815-23
Ren, H; Stiles, G L (1995) Separate promoters in the human A1 adenosine receptor gene direct the synthesis of distinct messenger RNAs that regulate receptor abundance. Mol Pharmacol 48:975-80
Olah, M E; Ren, H; Stiles, G L (1995) Adenosine receptors: protein and gene structure. Arch Int Pharmacodyn Ther 329:135-50
Palmer, T M; Gettys, T W; Stiles, G L (1995) Differential interaction with and regulation of multiple G-proteins by the rat A3 adenosine receptor. J Biol Chem 270:16895-902
Olah, M E; Jacobson, K A; Stiles, G L (1994) Identification of an adenosine receptor domain specifically involved in binding of 5'-substituted adenosine agonists. J Biol Chem 269:18016-20
Olah, M E; Gallo-Rodriguez, C; Jacobson, K A et al. (1994) 125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor. Mol Pharmacol 45:978-82
Ren, H; Stiles, G L (1994) Characterization of the human A1 adenosine receptor gene. Evidence for alternative splicing. J Biol Chem 269:3104-10
Palmer, T M; Gettys, T W; Jacobson, K A et al. (1994) Desensitization of the canine A2a adenosine receptor: delineation of multiple processes. Mol Pharmacol 45:1082-94
Ren, H; Stiles, G L (1994) Posttranscriptional mRNA processing as a mechanism for regulation of human A1 adenosine receptor expression. Proc Natl Acad Sci U S A 91:4864-66

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