Abstract

Thrombosis is one of the major problems of modern man and research directed to its control is a major health goal. The proposed program is designed to establish an interdisciplinary Thrombosis SCOR at Cornell University Medical College. The activity represents the combined interrelated efforts of nine major laboratories all working on the fundamental biochemical and physiological background of the human thrombotic process. The long-term aim of the program is to clarify and define thrombogenesis in meaningful clinical terms which may have eventual therapeutic relevance in man. An underlying theme which serves as a common denominator of the individual projects is the recognition and definition of the basic cellular and biochemical determinants of the thrombotic process. The coordinated interrelationships of platelets, endothelial cells and circulating protease inhibitors as important denominators of localized events will be stressed. Models to determine the etiology and pathogenesis of atherosclerosis will be studied.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL018828-14
Application #
3106536
Study Section
(SRC)
Project Start
1976-05-01
Project End
1991-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
14
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065

  Publications

Fabricant, C G; Fabricant, J (1999) Atherosclerosis induced by infection with Marek's disease herpesvirus in chickens. Am Heart J 138:S465-8
Crombie, R; Silverstein, R (1998) Lysosomal integral membrane protein II binds thrombospondin-1. Structure-function homology with the cell adhesion molecule CD36 defines a conserved recognition motif. J Biol Chem 273:4855-63
Camera, M; Hajjar, K A; Pan, S et al. (1998) Profibrinolytic properties characterize a stably transformed human endothelial cell line. Blood Coagul Fibrinolysis 9:153-65
Magnetto, S; Bruno-Bossio, G; Voland, C et al. (1998) CD36 mediates binding of soluble thrombospondin-1 but not cell adhesion and haptotaxis on immobilized thrombospondin-1. Cell Biochem Funct 16:211-21
Krause, I; Blumenfeld, Z; Malchinsky, M et al. (1998) Anti-endothelial cell antibodies in the sera of hyperprolactinemic women. Lupus 7:377-82
Zhang, Y J; Weksler, B B; Wang, L et al. (1998) Immunohistochemical detection of polycyclic aromatic hydrocarbon-DNA damage in human blood vessels of smokers and non-smokers. Atherosclerosis 140:325-31
Subbaramaiah, K; Zakim, D; Weksler, B B et al. (1997) Inhibition of cyclooxygenase: a novel approach to cancer prevention. Proc Soc Exp Biol Med 216:201-10
Subbaramaiah, K; Telang, N; Bansal, M B et al. (1997) Cyclooxygenase-2 gene expression is upregulated in transformed mammary epithelial cells. Ann N Y Acad Sci 833:179-85
Hermann, A; Laws, W R; Harpel, P C (1997) Oxidation of apolipoprotein(a) inhibits kringle-associated lysine binding: the loss of intrinsic protein fluorescence suggests a role for tryptophan residues in the lysine binding site. Protein Sci 6:2324-35
Schweitzer, K M; Vicart, P; Delouis, C et al. (1997) Characterization of a newly established human bone marrow endothelial cell line: distinct adhesive properties for hematopoietic progenitors compared with human umbilical vein endothelial cells. Lab Invest 76:25-36

Showing the most recent 10 out of 225 publications