Abstract

The purpose of the Experimental Laboratory Core is to Provide the space, equipment, trained personnel, and supplies necessary for animal experimentation. The total space allotted to this Core is approximately 2,100 square feet and includes a recently renovated surgical suite, a large laboratory for chronically instrumented animal experimentation, a plethysmograph laboratory for airway mechanics experimentation, and two separate small animal laboratories. The Core will be responsible for the upkeep and repair of all equipment necessary for the proposed animal experiments (e.g., strip-chart recorders, anesthesia machines, blood gas analyzer, CoulterCouner, etc.). The Core will be responsible for ordering, storing, and distributing all supplies required by the animal experimentation projects. In addition, the Experimental Laboratory Core will assist the Data Management Division of the Clinical Core in the development and implementation of data acquisition and databases software for the use of all investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL019153-21
Application #
6241612
Study Section
Project Start
1996-12-01
Project End
1997-11-30
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
21
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

Brigham, K L; Lane, K B; Meyrick, B et al. (2000) Transfection of nasal mucosa with a normal alpha1-antitrypsin gene in alpha1-antitrypsin-deficient subjects: comparison with protein therapy. Hum Gene Ther 11:1023-32
Conner, B D; Bernard, G R (2000) Acute respiratory distress syndrome. Potential pharmacologic interventions. Clin Chest Med 21:563-87
Mangialardi, R J; Martin, G S; Bernard, G R et al. (2000) Hypoproteinemia predicts acute respiratory distress syndrome development, weight gain, and death in patients with sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med 28:3137-45
Brigham, K L; Stecenko, A A (2000) Gene therapy for acute lung injury. Intensive Care Med 26 Suppl 1:S119-23
Arons, M M; Wheeler, A P; Bernard, G R et al. (1999) Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group. Crit Care Med 27:699-707
Peters, M T; Brigham, K L; King, G A et al. (1999) Optimization of cationic liposome-mediated gene transfer to human bronchial epithelial cells expressing wild-type or abnormal cystic fibrosis transmembrane conductance regulator (CFTR). Exp Lung Res 25:183-97
Wheeler, A P; Bernard, G R (1999) Treating patients with severe sepsis. N Engl J Med 340:207-14
Snapper, J R; Trochtenberg, D S; Hwang, Y S et al. (1999) Effect of pulmonary edema on tracheal diameter. Respiration 66:522-7
Alexander, J S; Patton, W F; Christman, B W et al. (1998) Platelet-derived lysophosphatidic acid decreases endothelial permeability in vitro. Am J Physiol 274:H115-22
Dupont, W D; Plummer Jr, W D (1998) Power and sample size calculations for studies involving linear regression. Control Clin Trials 19:589-601

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