Abstract

The Morphology/Ultrastructure Core Laboratory provides access to instrumentation, technical assistance, instruction, and consultation for SCOR investigators conducting cell biological and morphologic studies at the histologic and ultrastructural level. This centralized laboratory maintains access to a full range of light and electron microscopes, ancillary apparatus and preparative resources, computer assisted image, morphometric, and densitometric analysis, and a complete photographic facility. The laboratory is staffed by well qualified, experienced technicians under the direction of the Principal Investigator. Five proposed projects will rely extensively on the resources available in this unit and all projects will require periodic access to the photographic facility. The wide range of instrumentation and the cost effectiveness with which the laboratory is able to operate is directly attributable to shared support with other research units which also use the facility as a core laboratory.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL019171-19
Application #
3736130
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Price, Wayne A; Moats-Staats, Billie M; Stiles, Alan D (2002) Pro- and anti-inflammatory cytokines regulate insulin-like growth factor binding protein production by fetal rat lung fibroblasts. Am J Respir Cell Mol Biol 26:283-9
Gordon, Phillip V; Moats-Staats, Billie M; Stiles, Alan D et al. (2002) Dexamethasone changes the composition of insulin-like growth factor binding proteins in the newborn mouse ileum. J Pediatr Gastroenterol Nutr 35:532-8
Gordon, P V; Marshall, D D; Stiles, A D et al. (2001) The clinical, morphologic, and molecular changes in the ileum associated with early postnatal dexamethasone administration: from the baby's bowel to the researcher's bench. Mol Genet Metab 72:91-103
Gordon, P V; Price, W A; Stiles, A D et al. (2001) Early postnatal dexamethasone diminishes transforming growth factor alpha localization within the ileal muscularis propria of newborn mice and extremely low-birth-weight infants. Pediatr Dev Pathol 4:532-7
Stiles, A D; Chrysis, D; Jarvis, H W et al. (2001) Programmed cell death in normal fetal rat lung development. Exp Lung Res 27:569-87
Gordon, P V; Price, W A; Stiles, A D (2001) Dexamethasone administration to newborn mice alters mucosal and muscular morphology in the ileum and modulates IGF-I localization. Pediatr Res 49:93-100
Moats-Staats, B M; Jarvis, H W; Brighton, B et al. (2000) Regulation of the rat BB1 RNA during normal rat lung development. Exp Lung Res 26:401-20
Gordon, P; Rutledge, J; Sawin, R et al. (1999) Early postnatal dexamethasone increases the risk of focal small bowel perforation in extremely low birth weight infants. J Perinatol 19:573-7
Price, W A; Moats-Staats, B M; Sekhon, H S et al. (1998) Expression of the insulin-like growth factor system in postpneumonectomy lung growth. Exp Lung Res 24:203-17
Veness-Meehan, K A; Moats-Staats, B M; Maniscalco, W M et al. (1997) Changes in decorin expression with hyperoxic injury to developing rat lung. Pediatr Res 41:464-72

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