Abstract

The Arteriosclerosis SCOR at Columbia comprises a multidisciplinary and coordinated set of laboratory and clinical research activities within the broad field of atherosclerosis research. The SCOR program includes projects directed at major questions in the areas of lipid and lipoprotein metabolism, hyperlipidemia, atherogenesis, arterial cell biology and pathology, vascular eicosanoid and autocoid metabolism, and coronary heart disease. Two major integrating themes are: (1) the study of the metabolism of plasma lipoproteins and apolipoproteins in relation to atherosclerosis; and (2) investigations concerning atherogenesis and the cell biology of the arterial wall. A third, connecting theme deals with studies of interrelationships between lipoproteins, blood cells, and the arterial wall.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
2P50HL021006-16
Application #
3106582
Study Section
Special Emphasis Panel (SRC (SA))
Project Start
1976-12-01
Project End
1996-11-30
Budget Start
1992-01-01
Budget End
1992-11-30
Support Year
16
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Dangelmaier, Carol A; Holmsen, Holm (2014) Glyoxylate lowers metabolic ATP in human platelets without altering adenylate energy charge or aggregation. Platelets 25:36-44
Farwell, Wildon R; Sesso, Howard D; Buring, Julie E et al. (2005) Non-high-density lipoprotein cholesterol versus low-density lipoprotein cholesterol as a risk factor for a first nonfatal myocardial infarction. Am J Cardiol 96:1129-34
Cole, S R; Kawachi, I; Liu, S et al. (2001) Time urgency and risk of non-fatal myocardial infarction. Int J Epidemiol 30:363-9
Couch, S C; Cross, A T; Kida, K et al. (2000) Rapid westernization of children's blood cholesterol in 3 countries: evidence for nutrient-gene interactions? Am J Clin Nutr 72:1266S-1274S
Khaled, Z; Ho, Y Y; Benimetskaya, L et al. (1999) Omega-6 polyunsaturated fatty acid-stimulated cellular internalization of phosphorothioate oligodeoxynucleotides: evidence for protein kinase C-zeta dependency. Biochem Pharmacol 58:411-23
Gaziano, J M; Hennekens, C H; Godfried, S L et al. (1999) Type of alcoholic beverage and risk of myocardial infarction. Am J Cardiol 83:52-7
Gaziano, J M; Sesso, H D; Breslow, J L et al. (1999) Relation between systemic hypertension and blood lipids on the risk of myocardial infarction. Am J Cardiol 84:768-73
Sesso, H D; Gaziano, J M; Buring, J E et al. (1999) Coffee and tea intake and the risk of myocardial infarction. Am J Epidemiol 149:162-7
Arai, T; Wang, N; Bezouevski, M et al. (1999) Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene. J Biol Chem 274:2366-71
Barth, J A; Deckelbaum, R J; Starc, T J et al. (1999) Family history of early cardiovascular disease in children with moderate to severe hypercholesterolemia: relationship to lipoprotein (a) and low-density lipoprotein cholesterol levels. J Lab Clin Med 133:237-44

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