The central theme of this proposed SCOR is the role of sodium in hypertension. This is an appropriate theme for this group of investigators and for this particular time in the history of hypertension research. It is appropriate for these investigators because most have had many years of research experience either directly or indirectly concerned with sodium and hypertension. The timing is appropriate because the large backgroud of information available from decades of work indicates that a concerted, multifaceted effort should yield much needed insight into this pervasive problem. The hypertension Task Force of the National Heart, Lung and Blood Institute found, in its review of current knowlege, that questions concerning the role of sodium arose in most subgroup deliberations. The Task Force identified seven research areas that merit particular emphasis.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL025451-05
Application #
3106608
Study Section
(SRC)
Project Start
1980-09-01
Project End
1985-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
Overall Medical
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Jin, H; Yang, R; Chen, Y F et al. (1992) Ganglion atrial natriuretic peptide in NaCl sensitive spontaneously hypertensive rats. Am J Hypertens 5:806-10
Jin, H K; Yang, R H; Chen, Y F et al. (1991) Altered stores of atrial natriuretic peptide in specific brain nuclei of NaCl-sensitive spontaneously hypertensive rats. Am J Hypertens 4:449-55
Oparil, S; Chen, Y F; Jin, H K et al. (1991) Dietary Ca2+ prevents NaCl-sensitive hypertension in spontaneously hypertensive rats via sympatholytic and renal effects. Am J Clin Nutr 54:227S-236S
Oparil, S; Wyss, J M; Yang, R H et al. (1990) Dietary Ca2+ prevents NaCl-sensitive hypertension in spontaneously hypertensive rats by a sympatholytic mechanism. Am J Hypertens 3:179S-188S
Jirakulsomchok, S; Mozaffari, M S; Oparil, S et al. (1990) Dietary Ca2+ increases natriuretic and diuretic responses to volume loading in NaCl-sensitive spontaneously hypertensive rats. J Hypertens 8:947-51
Wyss, J M; Chen, Y F; Meng, Q C et al. (1989) Dietary Ca2+ prevents NaCl-induced exacerbation of hypertension and increases hypothalamic norepinephrine turnover in spontaneously hypertensive rats. J Hypertens 7:711-9
Jin, H K; Yang, R H; Chen, Y F et al. (1989) Hemodynamic effects of arginine vasopressin in rats adapted to chronic hypoxia. J Appl Physiol 66:151-60
Dustan, H P; Kirk, K A (1989) Corcoran lecture: the case for or against salt in hypertension. Arthur Curtis Corcoran, MD (1909-1965). Tribute and prelude to Corcoran Lecture of 1988. Hypertension 13:696-705
Jin, H K; Yang, R H; Chen, Y F et al. (1989) Dietary NaCl loading enhances antihypertensive effect of guanabenz in spontaneously hypertensive rats. Am J Hypertens 2:435-9
Curtis, J J; Luke, R G; Jones, P et al. (1988) Hypertension in cyclosporine-treated renal transplant recipients is sodium dependent. Am J Med 85:134-8

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