Abstract

The Clinical Core has two main goals: to support the projects of this SCOR proposal and to serve as a resource for collaboration with other SCOR centers. To fulfill these goals the Clinical Core personnel will identify patients at risk for and with ARDS, develop and manage a clinical data base on all of the patients and be responsible for the execution and analysis of all studies outlined in individual projects which involve patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL040784-08
Application #
5213705
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Publications

Moore, Frederick A (2010) Presidential address: imagination trumps knowledge. Am J Surg 200:671-7
Hybertson, Brooks M; Chung, Jin H; Fini, Mehdi A et al. (2005) Aerosol-administered alpha-tocopherol attenuates lung inflammation in rats given lipopolysaccharide intratracheally. Exp Lung Res 31:283-94
Moss, Marc; Parsons, Polly E; Steinberg, Kenneth P et al. (2003) Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med 31:869-77
Hybertson, Brooks M; Jepson, Eric K; Allard, Jenny D et al. (2003) Transforming growth factor beta contributes to lung leak in rats given interleukin-1 intratracheally. Exp Lung Res 29:361-73
Gao, Bifeng; Flores, Sonia C; Leff, Jonathan A et al. (2003) Synthesis and anti-inflammatory activity of a chimeric recombinant superoxide dismutase: SOD2/3. Am J Physiol Lung Cell Mol Physiol 284:L917-25
Nick, Jerry A; Young, Scott K; Arndt, Patrick G et al. (2002) Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase. J Immunol 169:5260-9
Lee, Young M; Hybertson, Brooks M; Cho, Hyun G et al. (2002) Platelet-activating factor induces lung inflammation and leak in rats: hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. J Lab Clin Med 140:312-9
Suratt, B T; Young, S K; Lieber, J et al. (2001) Neutrophil maturation and activation determine anatomic site of clearance from circulation. Am J Physiol Lung Cell Mol Physiol 281:L913-21
Avdi, N J; Nick, J A; Whitlock, B B et al. (2001) Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis. J Biol Chem 276:2189-99
Moss, M; Guidot, D M; Steinberg, K P et al. (2000) Diabetic patients have a decreased incidence of acute respiratory distress syndrome. Crit Care Med 28:2187-92

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