Abstract

The UW-Madison Specialized Center of Research on """"""""Lung Biology and Disease in Infants and Children"""""""" will be devoted to elucidation of the pathobiology of bronchopulmonary dysplasia (BPD), particularly the delineation of cellular and biochemical mechanisms potentially important in either the pathogenesis of neonatal lung injury or the repair processes that facilitate recovery from chronic respiratory insufficiency of infants. This mission will be addressed in a multidisciplinary research program featuring a combination of interrelated basic and clinical investigations designed to expedite the development and application of new knowledge that might improve our understanding and treatment of bronchopulmonary dysplasia. There will be four research projects entitled: 1. Assessment of the role of oxyradicals in the pathogenesis of BPD. 2. Retinol function in the pathogenesis and repair of BPD. 3. Calcium-dependent phospholipid-binding proteins as related to lung development, RDS, and BPD. 4. Effect of hyperoxia on alveolar type II cell proliferation and differentiation during neonatal lung growth. These investigation, will be facilitated by three core units providing: a) administrative services; b) biostatistics/computing resources and assistance; and c) research coordinating support.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL046478-04
Application #
2222955
Study Section
Special Emphasis Panel (SRC (MA))
Project Start
1991-12-30
Project End
1996-11-30
Budget Start
1994-12-01
Budget End
1995-11-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Pediatrics
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Grummer, M A; Zachman, R D (1998) Retinoic acid and dexamethasone affect RAR-beta and surfactant protein C mRNA in the MLE lung cell line. Am J Physiol 274:L1-7
Tsao, F H; Meyer, K C; Chen, X et al. (1998) Degradation of annexin I in bronchoalveolar lavage fluid from patients with cystic fibrosis. Am J Respir Cell Mol Biol 18:120-8
Zimmerman, J J; Gabbert, D; Shivpuri, C et al. (1998) Meter-dosed, inhaled beclomethasone attenuates bronchoalveolar oxyradical inflammation in premature infants at risk for bronchopulmonary dysplasia. Am J Perinatol 15:567-76
Zachman, R D; Grummer, M A (1998) Effect of maternal/fetal vitamin A deficiency on fetal rat lung surfactant protein expression and the response to prenatal dexamethasone. Pediatr Res 43:178-83
Ts'ao, C; Ward, W F; Molteni, A et al. (1997) Annexin I concentration and prostacyclin production in rat lung and alveolar macrophages following irradiation. Prostaglandins Leukot Essent Fatty Acids 56:99-104
Zimmerman, J J; Ciesielski, W; Lewandoski, J (1997) Neutrophil-mediated phospholipid peroxidation assessed by gas chromatography-mass spectroscopy. Am J Physiol 273:C653-61
Contreras, M; Hariharan, N; Lewandoski, J R et al. (1996) Bronchoalveolar oxyradical inflammatory elements herald bronchopulmonary dysplasia. Crit Care Med 24:29-37
Tsao, F H; Cheng, W; Chen, X et al. (1996) Isolation and sequencing of the cDNA encoding phosphatidylinositol transfer protein from rabbit lung. Gene 172:299-302
Zachman, R D; Samuels, D P; Brand, J M et al. (1996) Use of the intramuscular relative-dose-response test to predict bronchopulmonary dysplasia in premature infants. Am J Clin Nutr 63:123-9
Zimmerman, J J (1995) Bronchoalveolar inflammatory pathophysiology of bronchopulmonary dysplasia. Clin Perinatol 22:429-56

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