Abstract

This core will provide clinical care for the patients enrolled in the SCOR Proposal and will collect biological samples from the patents and prepare the samples for transport to the project laboratories in the SCOR project. This core will collect clinical information related to these cause and severity of ARDS that will be utilized in associating clinical events with inflammatory mediator concentrations and endothelial cell function abnormalities. The Core will be centered in the Shock/Trauma/Intermountain Respiratory ICU and will make use of the existing facility, computerized clinical data base, and personnel, as well as existing personnel and facilities from sample preparation at the clinical laboratory of the LDS Hospital. There will be extensive communication between the Core responsible investigator and the other investigators to help facilitate the accomplishment of project goals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL050153-02
Application #
3737135
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Yost, Christian C; Weyrich, Andrew S; Zimmerman, Guy A (2010) The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie 92:692-7
Gomes, Rachel N; Bozza, Fernando A; Amancio, Rodrigo T et al. (2006) Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock 26:41-9
Matthay, Michael A; Zimmerman, Guy A (2005) Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 33:319-27
Lindemann, Stephan W; Weyrich, Andrew S; Zimmerman, Guy A (2005) Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells. Trends Cardiovasc Med 15:9-17
Ishizaka, Akitoshi; Matsuda, Tomoyuki; Albertine, Kurt H et al. (2004) Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 286:L1088-94
Zimmerman, Guy A; McIntyre, Thomas M (2004) PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. Trends Mol Med 10:245-8
Wu, Xiaoqing; Zimmerman, Guy A; Prescott, Stephen M et al. (2004) The p38 MAPK pathway mediates transcriptional activation of the plasma platelet-activating factor acetylhydrolase gene in macrophages stimulated with lipopolysaccharide. J Biol Chem 279:36158-65
Lindemann, Stephan W; Yost, Christian C; Denis, Melvin M et al. (2004) Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A 101:7076-81
Yost, Christian C; Denis, Melvin M; Lindemann, Stephan et al. (2004) Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med 200:671-80
Hoidal, John R; Brar, S S; Sturrock, Anne B et al. (2003) The role of endogenous NADPH oxidases in airway and pulmonary vascular smooth muscle function. Antioxid Redox Signal 5:751-8

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