Abstract

This Core will provide suitable quantities of well-characterized cells and consistent, standardize biologic assays to the various projects. This will ensure reproducibility of biologic responses and assays, provide the resources and expertise to develop new assays and culture methods as needed, create efficiencies of scale and serve to integrate the various projects. The Core will interact extensively with the various projects, including the clinical arm. This work will be performed at a centralized Core facility, using existing resources and experienced personnel.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL050153-02
Application #
3737136
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Yost, Christian C; Weyrich, Andrew S; Zimmerman, Guy A (2010) The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. Biochimie 92:692-7
Gomes, Rachel N; Bozza, Fernando A; Amancio, Rodrigo T et al. (2006) Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock 26:41-9
Lindemann, Stephan W; Weyrich, Andrew S; Zimmerman, Guy A (2005) Signaling to translational control pathways: diversity in gene regulation in inflammatory and vascular cells. Trends Cardiovasc Med 15:9-17
Matthay, Michael A; Zimmerman, Guy A (2005) Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol 33:319-27
Ishizaka, Akitoshi; Matsuda, Tomoyuki; Albertine, Kurt H et al. (2004) Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 286:L1088-94
Zimmerman, Guy A; McIntyre, Thomas M (2004) PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. Trends Mol Med 10:245-8
Wu, Xiaoqing; Zimmerman, Guy A; Prescott, Stephen M et al. (2004) The p38 MAPK pathway mediates transcriptional activation of the plasma platelet-activating factor acetylhydrolase gene in macrophages stimulated with lipopolysaccharide. J Biol Chem 279:36158-65
Lindemann, Stephan W; Yost, Christian C; Denis, Melvin M et al. (2004) Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A 101:7076-81
Yost, Christian C; Denis, Melvin M; Lindemann, Stephan et al. (2004) Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med 200:671-80
Hoidal, John R; Brar, S S; Sturrock, Anne B et al. (2003) The role of endogenous NADPH oxidases in airway and pulmonary vascular smooth muscle function. Antioxid Redox Signal 5:751-8

Showing the most recent 10 out of 71 publications