Abstract

The role of the Repolarization Signal Processing Laboratory is to provide the technical information services and support for SCOR projects that require the acquisition, display, analysis, and archiving of electrocardiographic data. Functions of the core include algorithm develop and software implementations for data visualization, feature extraction and statistical analyses. In addition, the core will carry out basic signal processing on all ECGs recorded from patients and implement and maintain a database of patient information. We will also assist investigators in Projects 4 and 5 in developing the software tools required for specialized processing and analyses of electrocardiographic data. For these same projects, the core will be responsible for developing and implementing quality control and data security measures. The functions of this core will be essential for Projects 4 and 5 due to their heavy dependence on storage and processing of large quantities of electrocardiographic data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL052338-08
Application #
6576585
Study Section
Project Start
2002-01-01
Project End
2002-12-31
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
$206,722
Indirect Cost

  Institution

Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Lux, Robert L; Gettes, Leonard S (2011) Repolarization heterogeneity and rate dependency in a canine rapid pacing model of heart failure. J Electrocardiol 44:730-5
Lux, Robert L; Pope 3rd, C Arden (2009) Air pollution effects on ventricular repolarization. Res Rep Health Eff Inst :3-20; discussion 21-8
Segerson, Nathan M; Litwin, Sheldon E; Daccarett, Marcos et al. (2008) Scatter in repolarization timing predicts clinical events in post-myocardial infarction patients. Heart Rhythm 5:208-14
Valencik, Maria L; Zhang, Dongfang; Punske, Bonnie et al. (2006) Integrin activation in the heart: a link between electrical and contractile dysfunction? Circ Res 99:1403-10
Lux, Robert L; Gettes, Leonard S; Mason, Jay W (2006) Understanding proarrhythmic potential in therapeutic drug development: alternate strategies for measuring and tracking repolarization. J Electrocardiol 39:S161-4
Spitzer, Kenneth W; Pollard, Andrew E; Yang, Lin et al. (2006) Cell-to-cell electrical interactions during early and late repolarization. J Cardiovasc Electrophysiol 17 Suppl 1:S8-S14
Splawski, Igor; Yoo, Dana S; Stotz, Stephanie C et al. (2006) CACNA1H mutations in autism spectrum disorders. J Biol Chem 281:22085-91
Shusterman, Vladimir; Goldberg, Anna; London, Barry (2006) Upsurge in T-wave alternans and nonalternating repolarization instability precedes spontaneous initiation of ventricular tachyarrhythmias in humans. Circulation 113:2880-7
Skaluba, Stanislaw J; Bray, Bruce E; Litwin, Sheldon E (2005) Close coupling of systolic and diastolic function: combined assessment provides superior prediction of exercise capacity. J Card Fail 11:516-22
Chen, Tiehua; Inoue, Masashi; Sheets, Michael F (2005) Reduced voltage dependence of inactivation in the SCN5A sodium channel mutation delF1617. Am J Physiol Heart Circ Physiol 288:H2666-76

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