The overall objectives of the Pathology Core are: first, to use qualitative and quantitative morphological methods to provide as extensive as possible a pathological evaluation of each clinical and experimental specimen submitted for study; second, to undertake the collaborative development and assessment of new methods and techniques for the morphological evaluation of the mechanisms of arterial thrombosis; and third, to apply newly developed techniques to the pathological study of vascular thrombosis. This core has an excellent history of collaboration with the investigators of the current Thrombosis SCOR (see publications list) and we will continue this interaction in this new proposal(note numerous photomicrographs in the proposal).
The specific aims of the Pathology Core are: 1. Provide a resource for procuring, characterizing and managing of both clinical and experimental tissue samples for the projects of this SCOR. 2. Provide a full range of morphological techniques for identification of vascular wall and thrombus related cellular elements and proteins. 3. Provide morphometric and image processing techniques for the quantitative evaluation of clinical and experimental specimens. 4. To examine human myocardial tissues for changes in tissue factor antigen content in disease states, to examine human lung tissue for evidence of tissue factor expression and with smoking and other diseases, and to examine tissue factor expression in tumors associated with intravascular thrombotic events.
| Johnson-Huang, Leanne M; Suárez-Fariñas, Mayte; Sullivan-Whalen, Mary et al. (2010) Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques. J Invest Dermatol 130:2654-63 |
| Choi, Brian G; Vilahur, Gemma; Zafar, M Urooj et al. (2008) Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model. Atherosclerosis 201:76-84 |
| Khorana, Alok A; Ahrendt, Steven A; Ryan, Charlotte K et al. (2007) Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res 13:2870-5 |
| Worthley, Stephen G; Helft, Gerard; Corti, Roberto et al. (2007) Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atherosclerosis. Pathophysiol Haemost Thromb 36:9-17 |
| Corti, Roberto; Osende, Julio; Hutter, Randolph et al. (2007) Fenofibrate induces plaque regression in hypercholesterolemic atherosclerotic rabbits: in vivo demonstration by high-resolution MRI. Atherosclerosis 190:106-13 |
| Choi, Brian G; Novoselsky, Constantin A; Vilahur, Gemma et al. (2007) Validation study of a semi-automated program for quantification of atherosclerotic burden. J Cardiovasc Magn Reson 9:615-20 |
| White, R James; Meoli, David F; Swarthout, Robert F et al. (2007) Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol 293:L583-90 |
| Hathcock, James; Rusinova, Elena; Vaananen, Heikki et al. (2007) Lipid-bound factor Xa regulates tissue factor activity. Biochemistry 46:6134-40 |
| Pyo, Robert T; Sui, Jinliang; Dhume, Ashwini et al. (2006) CXCR4 modulates contractility in adult cardiac myocytes. J Mol Cell Cardiol 41:834-44 |
| Bogdanov, V Y; Kirk, R I; Miller, C et al. (2006) Identification and characterization of murine alternatively spliced tissue factor. J Thromb Haemost 4:158-67 |
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