Core - Assay

Morrissey, James H.

Abstract

This core unit is a resource available to the projects within the Thrombosis SCOR. Its function is to perform coagulation, ELIA, and DNA analyses on blood and plasma samples obtained from human patients and normal volunteers. An additional function is to facilitate the development of novel assay techniques.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Specialized Center (P50)
• Project #: 5P50HL054502-07
• Application #: 6564997
• Project Start: 2002-02-01
• Project End: 2003-01-31
• Support Year: 7
• Fiscal Year: 2002

Institution

• Name: University of Oklahoma Health Sciences Center
• DUNS #: 937727907
• City: Oklahoma City
• State: OK
• Country: United States
• Zip Code: 73117

Publications

Ireland, Helen A; Cooper, Jackie A; Drenos, Fotios et al. (2009) FVII, FVIIa, and downstream markers of extrinsic pathway activation differ by EPCR Ser219Gly variant in healthy men. Arterioscler Thromb Vasc Biol 29:1968-74

Looney, M R; Esmon, C T; Matthay, M A (2009) Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax 64:114-20

Stowell, Sean R; Cho, Moonjae; Feasley, Christa L et al. (2009) Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation. J Biol Chem 284:4989-99

Miller, G J; Ireland, H A; Cooper, J A et al. (2008) Relationship between markers of activated coagulation, their correlation with inflammation, and association with coronary heart disease (NPHSII). J Thromb Haemost 6:259-67

Govers-Riemslag, J W P; Smid, M; Cooper, J A et al. (2007) The plasma kallikrein-kinin system and risk of cardiovascular disease in men. J Thromb Haemost 5:1896-903

Zheng, X; Li, W; Song, Y et al. (2007) Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia. J Thromb Haemost 5:1394-400

Zheng, Xunzhen; Li, Weihong; Gu, Jian-Ming et al. (2007) Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood 109:1003-9

Qu, D; Wang, Y; Esmon, N L et al. (2007) Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. J Thromb Haemost 5:395-402

Kashiwagi, Aki; DiGirolamo, Carla M; Kanda, Yoshiaki et al. (2007) The postimplantation embryo differentially regulates endometrial gene expression and decidualization. Endocrinology 148:4173-84

Smith, Stephanie A; Mutch, Nicola J; Baskar, Deepak et al. (2006) Polyphosphate modulates blood coagulation and fibrinolysis. Proc Natl Acad Sci U S A 103:903-8