Abstract

Successful execution of the clinical project and provision of comparative human specimens for the experimental studies of the SCOR require an efficient core resource dedicated to clinical subject recruitment, skillful performance of appropriate studies and timely processing and distribution of tissues to investigator laboratories. Further, all projects require a central repository for management of data and an experienced team for their analysis and integration. This core is dedicated to provide these services.
Its specific aims are: 1. To identify and recruit clinical research subject to the Center in Support of the research projects 2. To assure safe and timely conduct of all bronchoscopy and supporting clinical studies, and coordinate the processing and distribution of research samples to appropriate labs 3. To provide data management and biostatistical support for all research projects and other cores. To accomplish these aims, and experienced team has been assembled, comprised of a bronchoscopist, and clinical research nurse and a consulting biostatistician under the direction of a senior clinical investigator and epidemiologist.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL056389-05
Application #
6417692
Study Section
Project Start
2000-12-01
Project End
2002-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
5
Fiscal Year
2001
Total Cost
$165,355
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Liu, Juan; Harberts, Erin; Tammaro, Antonella et al. (2014) IL-9 regulates allergen-specific Th1 responses in allergic contact dermatitis. J Invest Dermatol 134:1903-1911
Bhandari, Vineet; Choo-Wing, Rayman; Harijith, Anantha et al. (2012) Increased hyperoxia-induced lung injury in nitric oxide synthase 2 null mice is mediated via angiopoietin 2. Am J Respir Cell Mol Biol 46:668-76
Homer, Robert J; Elias, Jack A; Lee, Chun Gun et al. (2011) Modern concepts on the role of inflammation in pulmonary fibrosis. Arch Pathol Lab Med 135:780-8
Koh, Byung Hee; Hwang, Soo Seok; Kim, Joo Young et al. (2010) Th2 LCR is essential for regulation of Th2 cytokine genes and for pathogenesis of allergic asthma. Proc Natl Acad Sci U S A 107:10614-9
Chapoval, Svetlana P; Lee, Chun Geun; Tang, Chuyan et al. (2009) Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Clin Immunol 132:371-84
Pillemer, Brendan B L; Xu, Hui; Oriss, Timothy B et al. (2007) Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function. Eur J Immunol 37:2082-9
Ostroukhova, Marina; Qi, Zengbiao; Oriss, Timothy B et al. (2006) Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. J Clin Invest 116:996-1004
Ostroukhova, Marina; Seguin-Devaux, Carole; Oriss, Timothy B et al. (2004) Tolerance induced by inhaled antigen involves CD4(+) T cells expressing membrane-bound TGF-beta and FOXP3. J Clin Invest 114:28-38
Lee, Gap Ryol; Flavell, Richard A (2004) Transgenic mice which overproduce Th2 cytokines develop spontaneous atopic dermatitis and asthma. Int Immunol 16:1155-60
Ma, Bing; Zhu, Zhou; Homer, Robert J et al. (2004) The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol 172:1872-81

Showing the most recent 10 out of 39 publications