Abstract

: The Pathology Core will work with each of the four projects in the quantification and morphological evaluation of mouse atherosclerotic lesions, including immunohistochemical analysis. The specific services will include the following: (a) proximal aorta lesion area quantification; (b) en face analysis and cholesterol content of lesions; (c) morphological gradation of lesions; (d) identification of cells and specific molecules in mouse lesions by immunohistochemistry (IHC); and (e) statistical analysis of lesional data. Details regarding the use by each of the four projects, the professional staff, methods, and facilities appear after the Progress Report section.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL056984-08
Application #
6877758
Study Section
Project Start
2004-04-01
Project End
2007-03-31
Budget Start
2004-04-01
Budget End
2005-03-31
Support Year
8
Fiscal Year
2004
Total Cost
$74,966
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Chen, Han; Cade, Brian E; Gleason, Kevin J et al. (2018) Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol 58:391-401
Johnson, Dayna A; Hirsch, Jana A; Moore, Kari A et al. (2018) Associations Between the Built Environment and Objective Measures of Sleep: The Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol 187:941-950
Johnson, Dayna A; Lane, Jacqueline; Wang, Rui et al. (2017) Greater Cognitive Deficits with Sleep-disordered Breathing among Individuals with Genetic Susceptibility to Alzheimer Disease. The Multi-Ethnic Study of Atherosclerosis. Ann Am Thorac Soc 14:1697-1705
Cade, Brian E; Chen, Han; Stilp, Adrienne M et al. (2016) Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans. Am J Respir Crit Care Med 194:886-897
Mayurasakorn, Korapat; Williams, Jill J; Ten, Vadim S et al. (2011) Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. Curr Opin Clin Nutr Metab Care 14:158-67
Devlin, Cecilia M; Leventhal, Andrew R; Kuriakose, George et al. (2008) Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler Thromb Vasc Biol 28:1723-30
Pan, Meihui; Maitin, Vatsala; Parathath, Sajesh et al. (2008) Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proc Natl Acad Sci U S A 105:5862-7
Williams, Kevin Jon; Feig, Jonathan E; Fisher, Edward A (2008) Rapid regression of atherosclerosis: insights from the clinical and experimental literature. Nat Clin Pract Cardiovasc Med 5:91-102
Tabas, Ira; Williams, Kevin Jon; Boren, Jan (2007) Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 116:1832-44
Williams, Kevin Jon; Qiu, Gang; Usui, Hitomi Katoaka et al. (2007) Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol 171:1441-50

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