Abstract

The four projects in the SCOR will be interlined through the Mouse Core. The functions of the mouse core will be to (1) create transgenic mouse be oocyte injection of various expression vectors, (2) generate mutant mice by homologous recombination and blastocysts injection of modifier embryonic stem(es) cell, (3) set up inc intercrosses between various mutants and transgenic mouse strains, (4) provide advice and technical expertise to members of the four laboratories on mouse techniques, and (5) to maintain breeding colonies of the large number of transgenic and knockout mouse that can be provided to each laboratory as needed. Mice for the Core will be housed at Southwestern and UCSD and will be readily exchanged as needed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
1P50HL061033-01
Application #
6199848
Study Section
Project Start
1999-01-01
Project End
1999-12-31
Budget Start
Budget End
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390

  Publications

Hullinger, Thomas G; Montgomery, Rusty L; Seto, Anita G et al. (2012) Inhibition of miR-15 protects against cardiac ischemic injury. Circ Res 110:71-81
Song, Kunhua; Nam, Young-Jae; Luo, Xiang et al. (2012) Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature 485:599-604
Xin, Mei; Kim, Yuri; Sutherland, Lillian B et al. (2011) Regulation of insulin-like growth factor signaling by Yap governs cardiomyocyte proliferation and embryonic heart size. Sci Signal 4:ra70
Montgomery, Rusty L; Hullinger, Thomas G; Semus, Hillary M et al. (2011) Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure. Circulation 124:1537-47
O'Rourke, Jason R; Olson, Eric N (2011) Modulating the MicroRNArchitecture of an aging aorta. Circ Res 109:1098-9
Porrello, Enzo R; Olson, Eric N (2010) Building a new heart from old parts: stem cell turnover in the aging heart. Circ Res 107:1292-4
Kwon, Chulan; Qian, Li; Cheng, Paul et al. (2009) A regulatory pathway involving Notch1/beta-catenin/Isl1 determines cardiac progenitor cell fate. Nat Cell Biol 11:951-7
Barlow, Gillian M; Micales, Bruce; Chen, Xiao-Ning et al. (2002) Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum? Biochem Biophys Res Commun 293:881-91
Barlow, G M; Micales, B; Lyons, G E et al. (2001) Down syndrome cell adhesion molecule is conserved in mouse and highly expressed in the adult mouse brain. Cytogenet Cell Genet 94:155-62
Yamagishi, H; Yamagishi, C; Nakagawa, O et al. (2001) The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation. Dev Biol 239:190-203

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