A. INTRODUCTION An experienced interdisciplinary research team is formed to solve important basic science and clinical questions related to the goals of this SCOR project. The main purpose of the Biostatistics Core is to bring together the information from different sources into an integrated database, and coordinate the genetic and statistical analyses with the focused being on the main goals of the SCOR. Since ischemia is a complex, multi-factorial and genetically heterogeneous disorder, different types of investigations are now being proposed in this core, which will require distinctly different analytical methods. One of the major goals of this core is to choose appropriate analytical and statistical techniques for the analysis of data collected from different analytical methods. One of the major goals of this core is to choose appropriate analytical and statistical techniques for the analysis of data collected from different projects in this SCOR proposal, especially, focusing on the justification of the data analysis method to be used for each type of data generated. B.
Specific Aims : 1. Design and apply analytical methods to be used in the gene mapping and other quantitative studies associated with various projects in the SCOR. 2. Provide ongoing statistical consultation to research projects, focusing on issues such as experimental design, sample size, aptness and validity of models to be used, power consideration and interpretation of the results. 3. Maintain a dataflow system that insures accuracy, security, validation and archiving of all data collected for different projects of the SCOR.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
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Special Emphasis Panel (ZHL1)
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Medical College of Wisconsin
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Ohta, Masanori; Toyama, Kazuyoshi; Gutterman, David D et al. (2013) Ecto-5'-nucleotidase, CD73, is an endothelium-derived hyperpolarizing factor synthase. Arterioscler Thromb Vasc Biol 33:629-36
Kizhakekuttu, Tinoy J; Wang, Jingli; Dharmashankar, Kodlipet et al. (2012) Adverse alterations in mitochondrial function contribute to type 2 diabetes mellitus-related endothelial dysfunction in humans. Arterioscler Thromb Vasc Biol 32:2531-9
Miura, Hiroto; Toyama, Kazuyoshi; Pratt, Phillip F et al. (2011) Cigarette smoking impairs Na+-K+-ATPase activity in the human coronary microcirculation. Am J Physiol Heart Circ Physiol 300:H109-17
Toyama, Kazuyoshi; Wulff, Heike; Chandy, K George et al. (2008) The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest 118:3025-37
Broeckel, Ulrich; Hengstenberg, Christian; Mayer, Bjoern et al. (2007) A locus on chromosome 10 influences C-reactive protein levels in two independent populations. Hum Genet 122:95-102
Hattan, Naoichiro; Chilian, William M; Park, Frank et al. (2007) Restoration of coronary collateral growth in the Zucker obese rat: impact of VEGF and ecSOD. Basic Res Cardiol 102:217-23
Rogers, Paul A; Chilian, William M; Bratz, Ian N et al. (2007) H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. Am J Physiol Heart Circ Physiol 292:H1404-11
Rocic, Petra; Kolz, Christopher; Reed, Ryan et al. (2007) Optimal reactive oxygen species concentration and p38 MAP kinase are required for coronary collateral growth. Am J Physiol Heart Circ Physiol 292:H2729-36
Nilakantan, Vani; Zhou, Xianghua; Hilton, Gail et al. (2006) Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplants. J Thorac Cardiovasc Surg 131:898-906
Liu, Yanping; Bubolz, Aaron H; Shi, Yang et al. (2006) Peroxynitrite reduces the endothelium-derived hyperpolarizing factor component of coronary flow-mediated dilation in PECAM-1-knockout mice. Am J Physiol Regul Integr Comp Physiol 290:R57-65

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