Abstract

The Clinical Core will provide support for the two clinical projects, Project 1 (Matthay) and Project 2 (Wiener-Kronish). Essentially, this core will be a clinical coordinating center staffed to support the clinical studies. This clinical core will provide the organization, personnel and supplies for the screening and enrollment of eligible patients in the adult and pediatric intensive care units at Moffitt-Long Hospital and San Francisco General Hospital. The clinical core will also provide the support for acquisition and entry of patient data and patient specimens, data analysis, and monitoring of all aspects of the clinical studies so as to conform with Good Clinical Practice and NIHLBI, FDA, and UCSF IRB guidelines. This core will also provide statistical analysis of the data and the support to modify database collection as needed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
1P50HL074005-01
Application #
6820202
Study Section
Special Emphasis Panel (ZHL1-CSR-R (M1))
Project Start
2003-09-30
Project End
2008-06-30
Budget Start
2003-09-30
Budget End
2004-06-30
Support Year
1
Fiscal Year
2003
Total Cost
$387,577
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Beitler, Jeremy R; Thompson, B Taylor; Matthay, Michael A et al. (2015) Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med 43:1026-35
Pittet, Jean-François; Koh, Hidefumi; Fang, Xiaohui et al. (2013) HMGB1 accelerates alveolar epithelial repair via an IL-1?- and ?v?6 integrin-dependent activation of TGF-?1. PLoS One 8:e63907
Agrawal, Ashish; Zhuo, Hanjing; Brady, Sandra et al. (2012) Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol 303:L634-9
Fricks-Lima, J; Hendrickson, C M; Allgaier, M et al. (2011) Differences in biofilm formation and antimicrobial resistance of Pseudomonas aeruginosa isolated from airways of mechanically ventilated patients and cystic fibrosis patients. Int J Antimicrob Agents 37:309-15
Srinivasan, Ramya; Song, Yuanlin; Wiener-Kronish, Jeanine et al. (2011) Plasminogen activation inhibitor concentrations in bronchoalveolar lavage fluid distinguishes ventilator-associated pneumonia from colonization in mechanically ventilated pediatric patients. Pediatr Crit Care Med 12:21-7
Singh, G; Wu, B; Baek, M S et al. (2010) Secretion of Pseudomonas aeruginosa type III cytotoxins is dependent on pseudomonas quinolone signal concentration. Microb Pathog 49:196-203
Lynch, Susan V; Flanagan, Judith L; Sawa, Teiji et al. (2010) Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV - implications for anti-PcrV immunotherapy. Microb Pathog 48:197-204
Ware, Lorraine B; Koyama, Tatsuki; Billheimer, D Dean et al. (2010) Prognostic and pathogenetic value of combining clinical and biochemical indices in patients with acute lung injury. Chest 137:288-96
Roux, Jérémie; Carles, Michel; Koh, Hidefumi et al. (2010) Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem 285:4278-90
Goolaerts, Arnaud; Roux, Jérémie; Ganter, Michael T et al. (2010) Serotonin decreases alveolar epithelial fluid transport via a direct inhibition of the epithelial sodium channel. Am J Respir Cell Mol Biol 43:99-108

Showing the most recent 10 out of 64 publications