Abstract

The overall goal of the Clinical Core is to ascertain eligible study subjects, coordinate their participation in the study protocols, and acquire all relevant samples and data required for the investigations. It is of utmost importance to this Core and program that we include all eligible subjects regardless of race, gender, age or ethnicity, and that we assure their safety and well-being during the conduct of each protocol. All studies will be performed with IRB approval and according to IRB guidelines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL074731-05
Application #
7582372
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2008-02-01
Budget End
2009-01-31
Support Year
5
Fiscal Year
2008
Total Cost
$504,698
Indirect Cost

  Institution

Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

O'Byrne, Michael L; McBride, Michael G; Paridon, Stephen et al. (2018) Association of Habitual Activity and Body Mass Index in Survivors of Congenital Heart Surgery: A Study of Children and Adolescents With Tetralogy of Fallot, Transposition of the Great Arteries, and Fontan Palliation. World J Pediatr Congenit Heart Surg 9:177-184
Mercer-Rosa, Laura; Elci, Okan U; Pinto, Nelangi M et al. (2018) 22q11.2 Deletion Status and Perioperative Outcomes for Tetralogy of Fallot with Pulmonary Atresia and Multiple Aortopulmonary Collateral Vessels. Pediatr Cardiol 39:906-910
Mercer-Rosa, Laura; Zhang, Xuemei; Tanel, Ronn E et al. (2018) Perioperative Factors Influence the Long-Term Outcomes of Children and Adolescents with Repaired Tetralogy of Fallot. Pediatr Cardiol :
Agopian, A J; Goldmuntz, Elizabeth; Hakonarson, Hakon et al. (2017) Genome-Wide Association Studies and Meta-Analyses for Congenital Heart Defects. Circ Cardiovasc Genet 10:e001449
Bhat, Misha; Goldmuntz, Elizabeth; Fogel, Mark A et al. (2017) Longitudinal Validation of the Diastolic to Systolic Time-Velocity Integral Ratio as a Doppler-Derived Measure of Pulmonary Regurgitation in Patients with Repaired Tetralogy of Fallot. Pediatr Cardiol 38:240-246
Xie, Hongbo M; Werner, Petra; Stambolian, Dwight et al. (2017) Rare copy number variants in patients with congenital conotruncal heart defects. Birth Defects Res 109:271-295
Werner, Petra; Latney, Brande; Deardorff, Matthew A et al. (2016) MESP1 Mutations in Patients with Congenital Heart Defects. Hum Mutat 37:308-14
Li, You; Yagi, Hisato; Onuoha, Ezenwa Obi et al. (2016) DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS Genet 12:e1005821
Mercer-Rosa, Laura; Paridon, Stephen M; Fogel, Mark A et al. (2015) 22q11.2 deletion status and disease burden in children and adolescents with tetralogy of Fallot. Circ Cardiovasc Genet 8:74-81
John, Anitha S; Rychik, Jack; Khan, Munziba et al. (2014) 22q11.2 deletion syndrome as a risk factor for aortic root dilation in tetralogy of Fallot. Cardiol Young 24:303-10

Showing the most recent 10 out of 63 publications