Abstract

One fundamental theme of this SCCOR proposal is the development of genetic tools for understanding the mechanistic basis for diabetes-associated cardiovascular disease. The Applied Genomics Core (AGC, Core Unit B) will provide sample processing and analytical support to the Projects detailed in this application. Specifically, the AGC will: 1) Perform DNA extraction and analysis of single nucleotide polymorphisms and other genetic variants for Projects 4 and 5 of this application. 2) Provide gene informatics expertise to mine and annotate genetic variants in candidate genes will also be conducted to support Projects 1, 4, and 5.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL077113-05
Application #
7785984
Study Section
Special Emphasis Panel (ZHL1)
Project Start
2009-01-01
Project End
2009-12-31
Budget Start
2009-01-01
Budget End
2009-12-31
Support Year
5
Fiscal Year
2009
Total Cost
$444,920
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Oni-Orisan, Akinyemi; Cresci, Sharon; Jones, Philip G et al. (2018) Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome. Prostaglandins Other Lipid Mediat 138:15-22
Patel, Krishna K; Arnold, Suzanne V; Chan, Paul S et al. (2018) Validation of the Seattle angina questionnaire in women with ischemic heart disease. Am Heart J 201:117-123
Coverstone, Edward D; Bach, Richard G; Chen, LiShiun et al. (2018) A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction. Basic Res Cardiol 113:38
Patel, Krishna K; Arnold, Suzanne V; Jones, Philip G et al. (2018) Relation of Age and Health-Related Quality of Life to Invasive Versus Ischemia-Guided Management of Patients with Non-ST Elevation Myocardial Infarction. Am J Cardiol 121:789-795
Qintar, Mohammed; Sharma, Puza P; Pokharel, Yashashwi et al. (2017) Prevalence and predictors of elevated high-sensitivity C-reactive protein in post-myocardial infarction patients: Insights from the VIRGO and TRIUMPH registries. Clin Cardiol 40:1205-1211
Qintar, Mohammed; Smolderen, Kim G; Chan, Paul S et al. (2017) Preinfarct Health Status and the Use of Early Invasive Versus Ischemia-Guided Management in Non-ST-Elevation Acute Coronary Syndrome. Am J Cardiol 120:1062-1069
Smolderen, Kim G; Buchanan, Donna M; Gosch, Kensey et al. (2017) Depression Treatment and 1-Year Mortality After Acute Myocardial Infarction: Insights From the TRIUMPH Registry (Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status). Circulation 135:1681-1689
Dreyer, Rachel P; Dharmarajan, Kumar; Kennedy, Kevin F et al. (2017) Sex Differences in 1-Year All-Cause Rehospitalization in Patients After Acute Myocardial Infarction: A Prospective Observational Study. Circulation 135:521-531
Thompson, Lauren E; Masoudi, Frederick A; Gosch, Kensey L et al. (2017) Gender differences in the association between discharge hemoglobin and 12-month mortality after acute myocardial infarction. Clin Cardiol 40:1279-1284
Zewinger, Stephen; Kleber, Marcus E; Tragante, Vinicius et al. (2017) Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study. Lancet Diabetes Endocrinol 5:534-543

Showing the most recent 10 out of 129 publications