Abstract

INTRODUCTION. The Clinical Core (Core C) will support the two clinical projects, Projects 1 and 2. For both UCSF and Mayo sites, Core C will be responsible for (1) a sample repository, including storage and appropriate distribution of all biologic specimens, (2) establishing and managing a web-entry central database, (3) establishing the pre-test probability of any Transfusion Related Acute Lung Injury (TRALI) based on a post hoc expert review of radiology and clinical data, (4) providing laboratory facilities and personnel for HLA antigen/antibody testing of donor and recipient plasma, and finally (5) ensuring data safety and monitoring aspects of the research so as to conform to Good Clinical Practice and to NHLBI and local IRB guidelines.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL081027-05
Application #
7922632
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
5
Fiscal Year
2009
Total Cost
$396,878
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Toy, Pearl; Kleinman, Steven H; Looney, Mark R (2017) Proposed revised nomenclature for transfusion-related acute lung injury. Transfusion 57:709-713
Roubinian, Nareg H; Looney, Mark R; Keating, Sheila et al. (2017) Differentiating pulmonary transfusion reactions using recipient and transfusion factors. Transfusion 57:1684-1690
Roubinian, Nareg H; Looney, Mark R; Kor, Daryl J et al. (2015) Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions. Transfusion 55:1838-46
Toy, Pearl; Bacchetti, Peter; Grimes, Barbara et al. (2015) Recipient clinical risk factors predominate in possible transfusion-related acute lung injury. Transfusion 55:947-52
Feiner, John R; Gropper, Michael A; Toy, Pearl et al. (2015) A Clinical Trial to Detect Subclinical Transfusion-induced Lung Injury during Surgery. Anesthesiology 123:126-35
Looney, Mark R; Roubinian, Nareg; Gajic, Ognjen et al. (2014) Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*. Crit Care Med 42:1676-87
Murphy, Edward L; Kwaan, Nicholas; Looney, Mark R et al. (2013) Risk factors and outcomes in transfusion-associated circulatory overload. Am J Med 126:357.e29-38
Gandhi, Manish J; Carrick, Danielle M; Jenkins, Sarah et al. (2013) Lot-to-lot variability in HLA antibody screening using a multiplexed bead-based assay. Transfusion 53:1940-7
Rollins, Mark D; Molofsky, Ari B; Nambiar, Ashok et al. (2012) Two septic transfusion reactions presenting as transfusion-related acute lung injury from a split plateletpheresis unit. Crit Care Med 40:2488-91
Kor, Daryl J; Kashyap, Rahul; Weiskopf, Richard B et al. (2012) Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med 185:842-50

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