Abstract

The Sample Processing and Banking Core Laboratory will collect blood samples, aortic specimens as wellas clinical data from patients with aortic aneurysm, aortic dissection, and control population. The samplesand data banked in core laboratory will service as a resource for supporting the clinical, biochemical,pathological, proteomic, and genetic study of thoracic aneurysm and dissection. The Sample Processingand Banking Core Laboratory will interact with clinician, surgical groups, and research groups to establishstandardized protocols and perform sample harvesting, banking, and monitoring the quality of samplesbanked. This will allow efficiently sample processing as well as ensure high quality sample banking. Corelaboratory will provide these high quality samples to the research projects in the Specialized Center ofClinically Oriented Research (SCCOR) in Aortic Aneurysm and Dissection, which pursue the objectives ofdetermining the genetic variation in disease prediction, disease diagnosis, disease mechanisms, surgicalresponse, drug response, readmission, second events and survival.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
1P50HL083794-01
Application #
7140875
Study Section
Special Emphasis Panel (ZHL1-CSR-A (F1))
Project Start
2006-04-01
Project End
2011-03-31
Budget Start
2006-04-01
Budget End
2007-04-30
Support Year
1
Fiscal Year
2006
Total Cost
$140,615
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Type
DUNS #
800771594
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Prakash, Siddharth K; Milewicz, Dianna M (2018) X Marks the Spot: The Profound Impact of Sex on Aortic Disease. Arterioscler Thromb Vasc Biol 38:9-11
Guo, Dong-Chuan; Hostetler, Ellen M; Fan, Yuxin et al. (2017) Heritable Thoracic Aortic Disease Genes in Sporadic Aortic Dissection. J Am Coll Cardiol 70:2728-2730
Ren, Pingping; Hughes, Michael; Krishnamoorthy, Swapna et al. (2017) Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. Sci Rep 7:12351
Wu, Darrell; Ren, Pingping; Zheng, Yanqiu et al. (2017) NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation. Arterioscler Thromb Vasc Biol 37:694-706
Guo, Dong-Chuan; Grove, Megan L; Prakash, Siddharth K et al. (2016) Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections. Am J Hum Genet 99:762-769
Romere, Chase; Duerrschmid, Clemens; Bournat, Juan et al. (2016) Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell 165:566-79
van 't Hof, Femke N G; Ruigrok, Ynte M; Lee, Cue Hyunkyu et al. (2016) Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc 5:
Prakash, Siddharth; Kuang, Shao-Qing; GenTAC Registry Investigators et al. (2016) Recurrent Rare Genomic Copy Number Variants and Bicuspid Aortic Valve Are Enriched in Early Onset Thoracic Aortic Aneurysms and Dissections. PLoS One 11:e0153543
Starosolski, Zbigniew; Villamizar, Carlos A; Rendon, David et al. (2015) Ultra High-Resolution In vivo Computed Tomography Imaging of Mouse Cerebrovasculature Using a Long Circulating Blood Pool Contrast Agent. Sci Rep 5:10178
Regalado, Ellen S; Guo, Dong-chuan; Prakash, Siddharth et al. (2015) Aortic Disease Presentation and Outcome Associated With ACTA2 Mutations. Circ Cardiovasc Genet 8:457-64

Showing the most recent 10 out of 83 publications