The Biostatistics and Data Management Core (BDMC) will serve as a centralized resource to the investigators? of the proposed SCCOR Acute Aortic Dissection Project grant to insure that the dispersed elements of? program remain synchronized, and to providing database management and biostatistical services as needed.? The core will seve as a centralized resource for data acquisition and management, designing clinical and basic? science experiments, developing innovative statistical methodology, statistical analysis, and publishing? research results generated by the SCCOR projects.
The specific aims of the BDMC are:? 1. To assist in the planning and study design of the grant projects, including sample size and power? calculations and data analysis plans.? 2. To facilitate data collection, entry, quality control, and data integration among SCCOR projects which? include basic science, pre-clinical, clinical and epidemiologic projects.? 3. To develop a secure, web-based database management system for tracking, distribution and central? repository of genetic, socio-demographic, laboratory, biomarker, imaging and clinical data.? 4. To provide study monitoring that would ensure patient safety by timely reporting of adverse events to IRBs? and the Data Monitoring Committee.? 5. To conduct statistical analyses including descriptive analyses, hypothesis testing, estimation, and? construction of statistical models.? 6. To develop and apply innovative statistical methods pertienent to acute aortic dissection studies.? 7. To generate statsitical reports and to collaborate in publication of scientific results.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
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Special Emphasis Panel (ZHL1)
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University of Texas Health Science Center Houston
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Prakash, Siddharth K; Milewicz, Dianna M (2018) X Marks the Spot: The Profound Impact of Sex on Aortic Disease. Arterioscler Thromb Vasc Biol 38:9-11
Guo, Dong-Chuan; Hostetler, Ellen M; Fan, Yuxin et al. (2017) Heritable Thoracic Aortic Disease Genes in Sporadic Aortic Dissection. J Am Coll Cardiol 70:2728-2730
Ren, Pingping; Hughes, Michael; Krishnamoorthy, Swapna et al. (2017) Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice. Sci Rep 7:12351
Wu, Darrell; Ren, Pingping; Zheng, Yanqiu et al. (2017) NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation. Arterioscler Thromb Vasc Biol 37:694-706
Guo, Dong-Chuan; Grove, Megan L; Prakash, Siddharth K et al. (2016) Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections. Am J Hum Genet 99:762-769
Romere, Chase; Duerrschmid, Clemens; Bournat, Juan et al. (2016) Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell 165:566-79
van 't Hof, Femke N G; Ruigrok, Ynte M; Lee, Cue Hyunkyu et al. (2016) Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms. J Am Heart Assoc 5:
Prakash, Siddharth; Kuang, Shao-Qing; GenTAC Registry Investigators et al. (2016) Recurrent Rare Genomic Copy Number Variants and Bicuspid Aortic Valve Are Enriched in Early Onset Thoracic Aortic Aneurysms and Dissections. PLoS One 11:e0153543
Starosolski, Zbigniew; Villamizar, Carlos A; Rendon, David et al. (2015) Ultra High-Resolution In vivo Computed Tomography Imaging of Mouse Cerebrovasculature Using a Long Circulating Blood Pool Contrast Agent. Sci Rep 5:10178
Regalado, Ellen S; Guo, Dong-chuan; Prakash, Siddharth et al. (2015) Aortic Disease Presentation and Outcome Associated With ACTA2 Mutations. Circ Cardiovasc Genet 8:457-64

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