CORES: The imaging acquisition and analysis core was established in response to the growing need of several investigators for High-resolution CT image acquisition and analysis across a range of species. Since our publication of the first use of HRCT to assess airway reactivity in dogs, we have published several subsequent studies, using HRCT to measure airway walls and airway size changes in dogs, in sheep, and in humans. Due to developing needs, we have hired Dr. Masaru Ishii to expanding the imaging acquisition and analysis core unit to include Magnetic Resonance imaging, specifically hyperpolarized helium (3He) imaging acquisition and analysis. The strength of the imaging core has been demonstrated by our ability to acquire highly reproducible lung images for quantitative analysis of airways and parenchyma. Conventional pulmonary function measurements are unable to assess airway stiffness or reduced maximum airway size, as measured by changes in airway size with lung inflation. HRCT is a direct, noninvasive, radiological technique that can accurately and reliably measure airway luminal area and airway wall thickness in human airways in vivo. Using HRCT, one can make repeated airway luminal and airway wall thickness measurements of multiple airways at different lung volumes in vivo. In the proposed work, we will use HRCT to make repeated measures of airway size at various lung volumes, airway wall thickness in multiple airways (2nd to 8th generation airways), and lung parenchyma! density in subjects with COPD as an index of airway remodeling. Furthermore, the development of a consistent database of airway images will be instrumental in linking projects related to progression of COPD. HRCT also has been demonstrated to be a precise tool for the quantification of emphysema by measurement of lung parenchyma! density. In order to increase the sensitivity of this measurement of treatment and harmful exposures, we plan to evaluate regions of lung with low destructive index as a measure of COPD progression. The Core will support Projects 2 and 5 and will interact with Core C.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Specialized Center (P50)
Project #
5P50HL084945-04
Application #
8135386
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
4
Fiscal Year
2010
Total Cost
$273,581
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Robert, H Brown; Robert, A Wise; Kirk, Gregory et al. (2015) Lung density changes with growth and inflation. Chest 148:995-1002
Shin, Mi-Kyung; Yao, Qiaoling; Jun, Jonathan C et al. (2014) Carotid body denervation prevents fasting hyperglycemia during chronic intermittent hypoxia. J Appl Physiol (1985) 117:765-76
Sussan, Thomas E; Ingole, Vijendra; Kim, Jung-Hyun et al. (2014) Source of biomass cooking fuel determines pulmonary response to household air pollution. Am J Respir Cell Mol Biol 50:538-48
McGrath-Morrow, Sharon A; Lauer, Thomas; Collaco, Joseph M et al. (2014) Transcriptional responses of neonatal mouse lung to hyperoxia by Nrf2 status. Cytokine 65:4-9
Yao, Qiaoling; Shin, Mi-Kyung; Jun, Jonathan C et al. (2013) Effect of chronic intermittent hypoxia on triglyceride uptake in different tissues. J Lipid Res 54:1058-65
Aggarwal, Neil R; D'Alessio, Franco R; Eto, Yoshiki et al. (2013) Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol 48:635-46
Putcha, Nirupama; Puhan, Milo A; Hansel, Nadia N et al. (2013) Impact of co-morbidities on self-rated health in self-reported COPD: an analysis of NHANES 2001-2008. COPD 10:324-32
Nilius, Georg; Franke, Karl-Josef; Domanski, Ulrike et al. (2013) Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure. Adv Exp Med Biol 755:27-34
Lockett, Angelia D; Kimani, Samuel; Ddungu, Godfrey et al. (2013) ??-Antitrypsin modulates lung endothelial cell inflammatory responses to TNF-?. Am J Respir Cell Mol Biol 49:143-50
Drager, Luciano F; Yao, Qiaoling; Hernandez, Karen L et al. (2013) Chronic intermittent hypoxia induces atherosclerosis via activation of adipose angiopoietin-like 4. Am J Respir Crit Care Med 188:240-8

Showing the most recent 10 out of 75 publications