CORE STRUCTURE The Cardiovascular Pathology Core (Core C) will provide unified and validated measurements of several biomarkers of cardiovascular injury for Center Projects. Using state-of-the-art techniques, this Core has already established Standard Operating Procedures (SOPs) for the quantification of a range of biochemicals, metabolites, cytokines, and common and rare blood cells. While it is charged to address the existing needs of the current projects, the scope of the Core services will not be limited to the requirements of these projects. ]t will refine ongoing areas of exploration and strive for developing novel assays to expand its repertoire. The fertile and dynamic resources of the Core and the technical excellence of its investigators in cardiovascular pathology and toxicology will also enable other Tobacco Research Centers to interface with A-TRAC. The Core will be housed in the Baxter II building in the Health Sciences Center of UofL. The Core currently has state of the art equipment for all its needs. Among the flow cytometers, the Core has an LSR II (Becton Dickinson;San Jose, CA) an Acuri C6 II (Becton Dickinson) and a MoFlo Legacy cell sorter (Dako, Carpinteria, CA). Other essential equipment include a Cobas-Mira Plus chemistry analyzer, a CellDyn hematology analyzer, a Chrono-log aggregometer, a BioTek SynergyMX plate reader, and a Zeiss LSM 510 confocal microscope (for details of all equipment, see Resources). Additional equipment for histology, immunohistochemistry and microscopic imaging are also available to Core personnel.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Specialized Center (P50)
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Special Emphasis Panel (ZRG1)
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American Heart Association
United States
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Ko, Darae; Preis, Sarah R; Lubitz, Steven A et al. (2018) Relation of Orthostatic Hypotension With New-Onset Atrial Fibrillation (From the Framingham Heart Study). Am J Cardiol 121:596-601
Mead, Erin L; Cruz-Cano, Raul; Groom, Allison et al. (2018) Responses to cigarette health warning labels, harm perceptions and knowledge in a national sample of pregnant and non-pregnant women of reproductive age. Addict Behav 90:10-13
Kamimura, Daisuke; Cain, Loretta R; Mentz, Robert J et al. (2018) Cigarette Smoking and Incident Heart Failure: Insights From the Jackson Heart Study. Circulation 137:2572-2582
Nayor, Matthew; Enserro, Danielle M; Xanthakis, Vanessa et al. (2018) Comorbidities and Cardiometabolic Disease: Relationship With Longitudinal Changes in Diastolic Function. JACC Heart Fail 6:317-325
Hart, Joy L; Walker, Kandi L; Sears, Clara G et al. (2018) The 'state' of tobacco: Perceptions of tobacco among Appalachian youth in Kentucky. Tob Prev Cessat 4:
Olmedo, Pablo; Goessler, Walter; Tanda, Stefan et al. (2018) Metal Concentrations in e-Cigarette Liquid and Aerosol Samples: The Contribution of Metallic Coils. Environ Health Perspect 126:027010
Tibuakuu, Martin; Kianoush, Sina; DeFilippis, Andrew P et al. (2018) Usefulness of Lipoprotein-Associated Phospholipase A2 Activity and C-Reactive Protein in Identifying High-Risk Smokers for Atherosclerotic Cardiovascular Disease (from the Atherosclerosis Risk in Communities Study). Am J Cardiol 121:1056-1064
Li, Wenyuan; Nyhan, Marguerite M; Wilker, Elissa H et al. (2018) Recent exposure to particle radioactivity and biomarkers of oxidative stress and inflammation: The Framingham Heart Study. Environ Int 121:1210-1216
Lee, Alexander S; Hart, Joy L; Walker, Kandi L et al. (2018) Dual Users and Electronic Cigarette Only Users: Consumption and Characteristics. Int J Healthc Med Sci 4:111-116
Staerk, Laila; Wang, Biqi; Preis, Sarah R et al. (2018) Lifetime risk of atrial fibrillation according to optimal, borderline, or elevated levels of risk factors: cohort study based on longitudinal data from the Framingham Heart Study. BMJ 361:k1453

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